Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Many proteins exert their biological activities through small exposed surface regions called
epitopes that are folded peptides of well‐defined three‐dimensional structures. Short …

Within the canonical repertoire of the amino acid involved in protein biogenesis, proline
plays a unique role as an amino acid presenting a modified backbone rather than a side …

Peptide macrocycles have found applications that range from drug discovery to
nanomaterials. These ring-shaped molecules have shown remarkable capacity for …

As a versatile therapeutic modality, peptides attract much attention because of their great
binding affinity, low toxicity, and the capability of targeting traditionally “undruggable” protein …

The last decade has witnessed a renaissance of peptides as drugs. This progress, together
with advances in the structural behavior of peptides, has attracted the interest of the …

Cyclic peptides are promising scaffolds for drug development, attributable in part to their
increased conformational order compared to linear peptides. However, when optimizing the …

The site-selective modification of peptide backbones allows an outstanding fine-tuning of
peptide conformation, folding ability, and physico-chemical and biological properties …

Macrocyclic peptides represent promising scaffolds for chemical tools and potential
therapeutics. Synthetic methods for peptide macrocyclization are often hampered by C …

In the realm of high‐throughput screening (HTS), macrocyclic peptide libraries traditionally
necessitate decoding tags, essential for both library synthesis and identifying hit peptide …