Psychedelics are serotonin 2A receptor agonists that can lead to profound changes in
perception, cognition and mood. In this review, we focus on the basic neurobiology …

The past decade has witnessed exponentially growing interest in the lateral habenula (LHb)
owing to new discoveries relating to its critical role in regulating negatively motivated …

Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted
pathology that includes (but is not limited to) sensitivity to drug-associated cues, negative …

Rewards are both “liked” and “wanted,” and those 2 words seem almost interchangeable.
However, the brain circuitry that mediates the psychological process of “wanting” a particular …

In the past decades, reductionism has dominated both research directions and funding
policies in clinical psychology and psychiatry. The intense search for the biological basis of …

The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Recent clinical and preclinical evidence suggests that psychedelics and entactogens may
produce both rapid and sustained therapeutic effects across several indications. Currently …

In addition to producing profound subjective effects following acute administration,
psychedelic compounds can induce beneficial behavioral changes relevant to the treatment …

Experiential factors shape the neural circuits underlying social and emotional behavior from
the prenatal period to the end of life. These factors include both incidental influences, such …

Recent neuroimaging studies suggest that the brain adapts with pain, as well as imparts risk
for develo** chronic pain. Within this context, we revisit the concepts for nociception, acute …