Current and future perspectives of liquid biopsies in genomics-driven oncology

E Heitzer, IS Haque, CES Roberts… - Nature Reviews …, 2019 - nature.com
Precision oncology seeks to leverage molecular information about cancer to improve patient
outcomes. Tissue biopsy samples are widely used to characterize tumours but are limited by …

Monitoring and adapting cancer treatment using circulating tumor DNA kinetics: Current research, opportunities, and challenges

E Sanz-Garcia, E Zhao, SV Bratman, LL Siu - Science Advances, 2022 - science.org
Circulating tumor DNA (ctDNA) has emerged as a biomarker with wide-ranging applications
in cancer management. While its role in guiding precision medicine in certain tumors via …

[HTML][HTML] ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group

J Pascual, G Attard, FC Bidard, G Curigliano… - Annals of …, 2022 - Elsevier
Circulating tumour DNA (ctDNA) assays conducted on plasma are rapidly develo** a
strong evidence base for use in patients with cancer. The European Society for Medical …

Clinical applications of circulating tumor cells and circulating tumor DNA as liquid biopsy

C Alix-Panabières, K Pantel - Cancer discovery, 2016 - AACR
Abstract “Liquid biopsy” focusing on the analysis of circulating tumor cells (CTC) and
circulating cell-free tumor DNA (ctDNA) in the blood of patients with cancer has received …

Cancer diagnosis: from tumor to liquid biopsy and beyond

R Vaidyanathan, RH Soon, P Zhang, K Jiang, CT Lim - Lab on a Chip, 2019 - pubs.rsc.org
Technological advancements in research on circulating biomarkers from patient derived
blood have enabled a less invasive means of diagnosing non-hematologic cancers …

The biology of circulating tumor cells

K Pantel, MR Speicher - Oncogene, 2016 - nature.com
Metastasis is a biologically complex process consisting of numerous stochastic events which
may tremendously differ across various cancer types. Circulating tumor cells (CTCs) are …

Current and future clinical applications of ctDNA in immuno-oncology

JC Stadler, Y Belloum, B Deitert, M Sementsov… - Cancer Research, 2022 - AACR
Testing peripheral blood for circulating tumor DNA (ctDNA) offers a minimally invasive
opportunity to diagnose, characterize, and monitor the disease in individual cancer patients …

Circulating tumor DNA and liquid biopsy: opportunities, challenges, and recent advances in detection technologies

L Gorgannezhad, M Umer, MN Islam, NT Nguyen… - Lab on a Chip, 2018 - pubs.rsc.org
Cell-free DNA (cfDNA) refers to short fragments of acellular nucleic acids detectable in
almost all body fluids, including blood, and is involved in various physiological and …

Tailored point-of-care biosensors for liquid biopsy in the field of oncology

S Singh, PS Podder, M Russo, C Henry, S Cinti - Lab on a Chip, 2023 - pubs.rsc.org
In the field of cancer detection, technologies to analyze tumors using biomarkers circulating
in fluids such as blood have developed rapidly based on liquid biopsy. A proactive approach …

Inferring expressed genes by whole-genome sequencing of plasma DNA

P Ulz, GG Thallinger, M Auer, R Graf, K Kashofer… - Nature …, 2016 - nature.com
The analysis of cell-free DNA (cfDNA) in plasma represents a rapidly advancing field in
medicine. cfDNA consists predominantly of nucleosome-protected DNA shed into the …