In this essay, we revisit the status of yeast as a model system for biology. We first summarize
important contributions of yeast to eukaryotic biology that we anticipated in 1988 in our first …

Gene duplication provides raw material for functional innovation. Recent advances have
shed light on two fundamental questions regarding gene duplication: which genes tend to …

Intrinsically disordered regions (IDRs) are ubiquitous across all domains of life and play a
range of functional roles. While folded domains are generally well-described by a stable 3D …

Transcription factors (TFs) that bind common DNA motifs in vitro occupy distinct sets of
promoters in vivo, raising the question of how binding specificity is achieved. TFs are …

In this update paper, we present the latest developments in the OMA browser
knowledgebase, which aims to provide high-quality orthology inferences and facilitate the …

INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

There are several hundred million protein sequences, but the relationships among them are
not fully available from existing homolog detection methods. There is an essential need for …

To tackle incongruence, the topological conflict between different gene trees, phylogenomic
studies couple concatenation with practices such as rogue taxon removal or the use of …

Genes for which homologs can be detected only in a limited group of evolutionarily related
species, called “lineage-specific genes,” are pervasive: Essentially every lineage has them …

INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …