Duchenne muscular dystrophy (DMD) is a monogenic muscle-wasting disorder and a
priority candidate for molecular and cellular therapeutics. Although rare, it is the most …

Skeletal muscles are essential for vital functions such as movement, postural support,
breathing, and thermogenesis. Muscle tissue is largely composed of long, postmitotic …

Despite many reports of putative stem-cell-based treatments in genetic and degenerative
disorders or severe injuries, the number of proven stem cell therapies has remained small …

Neuromuscular disorders encompass a heterogeneous group of conditions that impair the
function of muscles, motor neurons, peripheral nerves, and neuromuscular junctions. Being …

Skeletal muscles have a robust capacity to regenerate, but under compromised conditions,
such as severe trauma, the loss of muscle functionality is inevitable. Research carried out in …

Satellite cells are tissue resident muscle stem cells required for postnatal skeletal muscle
growth and repair through replacement of damaged myofibers. Muscle regeneration is …

Skeletal muscle mass is subject to rapid changes according to growth stimuli inducing both
hypertrophy, through increased protein synthesis, and hyperplasia, activating the myogenic …

Satellite cells are situated beneath the basal lamina that surrounds each myofiber and
function as myogenic precursors for muscle growth and repair. The source of satellite cell …

Skeletal muscle damaged by injury or by degenerative diseases such as muscular
dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon …

ALTHOUGH murine X-linked muscular dystrophy (mdx) and Duchenne muscular dystrophy
(DMD) are genetically homologous and both characterized by a complete absence of …