Mental ill health, which has been the leading health and social issue impacting the lives and
futures of young people for decades, has entered a dangerous phase. Accumulating …

The increase of mental health problems and the need for effective medical health care have
led to an investigation of machine learning that can be applied in mental health problems …

Background Psychological treatments occupy an important place in evidence-based mental
health treatments. Now is an exciting time to fuel treatment research: a pressing demand for …

Objective: Research and clinical translation in schizophrenia is limited by inconsistent
definitions of treatment resistance and response. To address this issue, the authors …

Objective: Approximately 20%–35% of individuals 12–35 years old who meet criteria for a
prodromal risk syndrome convert to psychosis within 2 years. However, this estimate ignores …

The concept of schizophrenia only covers the 30% poor outcome fraction of a much broader
multidimensional psychotic syndrome, yet paradoxically has become the dominant prism …

Finite mixture models, which are a type of latent variable model, express the overall
distribution of one or more variables as a mixture of a finite number of component …

Context During the past 2 decades, a major transition in the clinical characterization of
psychotic disorders has occurred. The construct of a clinical high-risk (HR) state for …

Over the past decade, our understanding of the role of stress in serious mental illness has
become more sophisticated. In this paper, we revisit the neural diathesis-stress model of …

Context A substantial proportion of people at clinical high risk of psychosis will develop a
psychotic disorder over time. However, the risk of transition to psychosis varies between …