Transposable elements (TEs) are genomic parasites that selfishly replicate at the expense of
host fitness. Fifty years of evolutionary studies of TEs have concentrated on the deleterious …

Intratumour heterogeneity and phenotypic plasticity, sustained by a range of somatic
aberrations, as well as epigenetic and metabolic adaptations, are the principal mechanisms …

Inherited IL-12Rβ1 and TYK2 deficiencies impair both IL-12–and IL-23–dependent IFN-γ
immunity and are rare monogenic causes of tuberculosis, each found in less than 1/600,000 …

Approximately 13% of the human genome can fold into non-canonical (non-B) DNA
structures (eg G-quadruplexes, Z-DNA, etc.), which have been implicated in vital cellular …

Ecological and demographic factors can significantly shape the evolution of microbial
populations both directly and indirectly, as when changes in the effective population size …

Interactions between mutations (epistasis) can add substantial complexity to genotype-
phenotype maps, hampering our ability to predict evolution. Yet, recent studies have shown …

Population Genetics and Microevolutionary Theory Explore the fundamentals of the
biological implications of population genetic theory In the newly revised Second Edition of …

Despite evolutionary biology's obsession with natural selection, few studies have evaluated
multigenerational series of patterns of selection on a genome-wide scale in natural …

In rapidly adapting asexual populations, including many microbial pathogens and viruses,
numerous mutant lineages often compete for dominance within the population,,,–. These …

Evolution in a static laboratory environment often proceeds via large-effect beneficial
mutations that may become maladaptive in other environments. Conversely, natural settings …