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Tumor evolution: Linear, branching, neutral or punctuated?
Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …
how this genetic diversity emerges over time remains limited. A central challenge in studying …
Rethinking ovarian cancer: recommendations for improving outcomes
There have been major advances in our understanding of the cellular and molecular biology
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …
of the human malignancies that are collectively referred to as ovarian cancer. At a recent …
The evolution of tumour phylogenetics: principles and practice
Rapid advances in high-throughput sequencing and a growing realization of the importance
of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies …
of evolutionary theory to cancer genomics have led to a proliferation of phylogenetic studies …
Cancer evolution: mathematical models and computational inference
Cancer is a somatic evolutionary process characterized by the accumulation of mutations,
which contribute to tumor growth, clinical progression, immune escape, and drug resistance …
which contribute to tumor growth, clinical progression, immune escape, and drug resistance …
Intra-tumor genetic heterogeneity and mortality in head and neck cancer: analysis of data from the Cancer Genome Atlas
Background Although the involvement of intra-tumor genetic heterogeneity in tumor
progression, treatment resistance, and metastasis is established, genetic heterogeneity is …
progression, treatment resistance, and metastasis is established, genetic heterogeneity is …
Metabolic adaptations in cancer stem cells
Cancer stem cells (CSCs) are a small and elusive subpopulation of self-renewing cancer
cells with remarkable ability to initiate, propagate, and spread the malignant disease. In …
cells with remarkable ability to initiate, propagate, and spread the malignant disease. In …
The influence of subclonal resistance mutations on targeted cancer therapy
Clinical oncology is being revolutionized by the increasing use of molecularly targeted
therapies. This paradigm holds great promise for improving cancer treatment; however …
therapies. This paradigm holds great promise for improving cancer treatment; however …
Insight into the heterogeneity of breast cancer through next-generation sequencing
Rapid and sophisticated improvements in molecular analysis have allowed us to sequence
whole human genomes as well as cancer genomes, and the findings suggest that we may …
whole human genomes as well as cancer genomes, and the findings suggest that we may …
Cancer stem cells (CSCs), cervical CSCs and targeted therapies
Accumulating evidence has shown that cancer stem cells (CSCs) have a tumour-initiating
capacity and play crucial roles in tumour metastasis, relapse and chemo/radio-resistance …
capacity and play crucial roles in tumour metastasis, relapse and chemo/radio-resistance …
Phylogenetic quantification of intra-tumour heterogeneity
Intra-tumour genetic heterogeneity is the result of ongoing evolutionary change within each
cancer. The expansion of genetically distinct sub-clonal populations may explain the …
cancer. The expansion of genetically distinct sub-clonal populations may explain the …