Tumor biomarkers for diagnosis, prognosis and targeted therapy

Y Zhou, L Tao, J Qiu, J Xu, X Yang, Y Zhang… - Signal transduction and …, 2024 - nature.com
Tumor biomarkers, the substances which are produced by tumors or the body's responses to
tumors during tumorigenesis and progression, have been demonstrated to possess critical …

Small molecules in targeted cancer therapy: advances, challenges, and future perspectives

L Zhong, Y Li, L **ong, W Wang, M Wu… - Signal transduction and …, 2021 - nature.com
Due to the advantages in efficacy and safety compared with traditional chemotherapy drugs,
targeted therapeutic drugs have become mainstream cancer treatments. Since the first …

Angiogenesis analyzer for ImageJ—A comparative morphometric analysis of “endothelial tube formation assay” and “fibrin bead assay”

G Carpentier, S Berndt, S Ferratge, W Rasband… - Scientific reports, 2020 - nature.com
Angiogenesis assays based on in vitro capillary-like growth of endothelial cells (EC) are
widely used, either to evaluate the effect of anti-and pro-angiogenesis drugs of interest, or to …

Targeting the tumour vasculature: from vessel destruction to promotion

S Guelfi, K Hodivala-Dilke, G Bergers - Nature Reviews Cancer, 2024 - nature.com
As angiogenesis was recognized as a core hallmark of cancer growth and survival, several
strategies have been implemented to target the tumour vasculature. Yet to date, attempts …

Angiogenesis as a hallmark of solid tumors-clinical perspectives

J Majidpoor, K Mortezaee - Cellular Oncology, 2021 - Springer
Background Angiogenesis is a key and early step in tumorigenesis, and is known as a
hallmark of solid tumors and a key promoter of tumor recurrence. Unlike normal tissue …

[HTML][HTML] The role of angiogenesis in cancer treatment

M Rajabi, SA Mousa - Biomedicines, 2017 - mdpi.com
A number of anti-angiogenesis drugs have been FDA-approved and are being used in
cancer treatment, and a number of other agents are in different stages of clinical …

Toward a mathematical theory of Keller–Segel models of pattern formation in biological tissues

N Bellomo, A Bellouquid, Y Tao… - Mathematical Models and …, 2015 - World Scientific
This paper proposes a survey and critical analysis focused on a variety of chemotaxis
models in biology, namely the classical Keller–Segel model and its subsequent …

[HTML][HTML] Vascular endothelial growth factor receptor (VEGFR-2)/KDR inhibitors: medicinal chemistry perspective

SJ Modi, VM Kulkarni - Medicine in Drug Discovery, 2019 - Elsevier
New blood vessels formation from the existing vasculature is called angiogenesis. It is an
essential physiological process for the growth of cells, tissue repair, wound healing, and …

Unraveling the role of angiogenesis in cancer ecosystems

I Zuazo-Gaztelu, O Casanovas - Frontiers in Oncology, 2018 - frontiersin.org
Activation of the tumor and stromal cell-driven angiogenic program is one of the first
requirements in the tumor ecosystem for growth and dissemination. The understanding of …

The contribution of angiogenesis to the process of metastasis

DR Bielenberg, BR Zetter - The Cancer Journal, 2015 - journals.lww.com
The role of angiogenesis in tumor growth has been studied continuously for over 45 years. It
is now appreciated that angiogenesis is also essential for the dissemination and …