Recent findings in yeast genetics and genomics have advanced our understanding of the
evolutionary potential unlocked by hybridization, especially in the genus Saccharomyces …

Phenotypic plasticity, the ability of an organism to display different phenotypes across
environments, is widespread in nature. Plasticity aids survival in novel environments …

The emergence of microbial antibiotic resistance is a global health threat. In clinical settings,
the key to controlling spread of resistant strains is accurate and rapid detection. As …

Structural rearrangements have long been recognized as an important source of genetic
variation, with implications in phenotypic diversity and disease, yet their detailed …

In diploid species, genetic loci can show additive, dominance, and epistatic effects. To
characterize the contributions of these different types of genetic effects to heritable traits, we …

The capacity to map traits over large cohorts of individuals—phenomics—lags far behind the
explosive development in genomics. For microbes, the estimation of growth is the key …

The consequence of a mutation can be influenced by the context in which it operates. For
example, loss of gene function may be tolerated in one genetic background, and lethal in …

Purpose Epistasis, the interaction between two or more genes, is integral to the study of
genetics and is present throughout nature. Yet, it is seldom fully explored as most …

Mutations, recombinations, and genome duplications may promote genetic diversity and
trigger evolutionary processes. However, quantifying these events in diploid hybrid …

Within quantitative genetics, the term “epistasis” is used to broadly describe situations in
which combinations of genetic variants show nonadditive phenotypic effects (Phillips 1998 …