Pathogenicity and virulence of Mycobacterium tuberculosis

KC Rahlwes, BRS Dias, PC Campos… - Virulence, 2023‏ - Taylor & Francis
Mycobacterium tuberculosis (Mtb) is the causative agent of tuberculosis, an infectious
disease with one of the highest morbidity and mortality rates worldwide. Leveraging its …

Immunology of Mycobacterium tuberculosis Infections

JK Sia, J Rengarajan - Microbiology spectrum, 2019‏ - journals.asm.org
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

Mycobacterium tuberculosis infection of host cells in space and time

C Bussi, MG Gutierrez - FEMS microbiology reviews, 2019‏ - academic.oup.com
Tuberculosis (TB) caused by the bacterial pathogen Mycobacterium tuberculosis (Mtb)
remains one of the deadliest infectious diseases with over a billion deaths in the past 200 …

Evolution of Drug-Resistant Mycobacterium tuberculosis Strains and Their Adaptation to the Human Lung Environment

A Allué-Guardia, JI García, JB Torrelles - Frontiers in microbiology, 2021‏ - frontiersin.org
In the last two decades, multi (MDR), extensively (XDR), extremely (XXDR) and total (TDR)
drug-resistant Mycobacterium tuberculosis (M. tb) strains have emerged as a threat to public …

Mycobacterium tuberculosis-macrophage interaction: Molecular updates

H Bo, UAE Moure, Y Yang, J Pan, L Li… - Frontiers in cellular …, 2023‏ - frontiersin.org
Mycobacterium tuberculosis (Mtb), the causative agent of Tuberculosis (TB), remains a
pathogen of great interest on a global scale. This airborne pathogen affects the lungs, where …

The Macrophage: A Disputed Fortress in the Battle against Mycobacterium tuberculosis

CJ Queval, R Brosch, R Simeone - Frontiers in microbiology, 2017‏ - frontiersin.org
Mycobacterium tuberculosis (Mtb), the etiological agent of human tuberculosis (TB), has
plagued humans for thousands of years. TB still remains a major public health problem in …

Patterns, receptors, and signals: regulation of phagosome maturation

AM Pauwels, M Trost, R Beyaert, E Hoffmann - Trends in immunology, 2017‏ - cell.com
Recognition of microbial pathogens and dead cells and their phagocytic uptake by
specialized immune cells are essential to maintain host homeostasis. Phagosomes undergo …

[HTML][HTML] Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages

MG Gutierrez, SS Master, SB Singh, GA Taylor… - Cell, 2004‏ - cell.com
Mycobacterium tuberculosis is an intracellular pathogen persisting within phagosomes
through interference with phagolysosome biogenesis. Here we show that stimulation of …

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

SM Batt, DE Minnikin, GS Besra - Biochemical Journal, 2020‏ - portlandpress.com
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Antimicrobial mechanisms of phagocytes and bacterial evasion strategies

RS Flannagan, G Cosío, S Grinstein - Nature Reviews Microbiology, 2009‏ - nature.com
Professional phagocytes have a vast and sophisticated arsenal of microbicidal features.
They are capable of ingesting and destroying invading organisms, and can present …