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Comprehensive review of CRISPR-based gene editing: mechanisms, challenges, and applications in cancer therapy
M Chehelgerdi, M Chehelgerdi… - Molecular cancer, 2024 - Springer
The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …
[HTML][HTML] Optimizing CRISPR/Cas9 precision: Mitigating off-target effects for safe integration with photodynamic and stem cell therapies in cancer treatment
CRISPR/Cas9 precision genome editing has revolutionized cancer treatment by introducing
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …
specific alterations to the cancer genome. But the therapeutic potential of CRISPR/Cas9 is …
[HTML][HTML] Multifaceted entrancing role of glucose and its analogue, 2-deoxy-D-glucose in cancer cell proliferation, inflammation, and virus infection
S Dey, N Murmu, T Mondal, I Saha, S Chatterjee… - Biomedicine & …, 2022 - Elsevier
Chronic exposure to high glucose inside the human body helps in the progression of cancer
by activating various signaling pathways including PI3K, Akt, mTOR, Ras, Raf, MAPK, and …
by activating various signaling pathways including PI3K, Akt, mTOR, Ras, Raf, MAPK, and …
[HTML][HTML] MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway
MARKs kinase belongs to an AMPK-related family kinase plays a critical role in tumor
progression, but its exact role and contribution of four different isoforms remain largely …
progression, but its exact role and contribution of four different isoforms remain largely …
PI3K/AKT/mTOR pathway, hypoxia, and glucose metabolism: Potential targets to overcome radioresistance in small cell lung cancer
H Deng, Y Chen, P Li, Q Hang, P Zhang… - Cancer Pathogenesis …, 2023 - mednexus.org
Small cell lung cancer (SCLC) is a highly aggressive tumor type for which limited therapeutic
progress has been made. Platinum-based chemotherapy with or without thoracic …
progress has been made. Platinum-based chemotherapy with or without thoracic …
YY1 transcription factor induces proliferation and aerobic glycolysis of neuroblastoma cells via LDHA regulation
Q Wang, W Fan, B Liang, B Hou… - Experimental and …, 2022 - spandidos-publications.com
The present study investigated the effect of transcription factor yin yang 1 (YY1) on aerobic
glycolysis and cell proliferation in neuroblastoma and its mechanism. Neuroblastoma cell …
glycolysis and cell proliferation in neuroblastoma and its mechanism. Neuroblastoma cell …
Role of MARK2 in the nervous system and cancer
Y Lei, R Zhang, F Cai - Cancer Gene Therapy, 2024 - nature.com
Abstract Microtubule-Affinity Regulating Kinase 2 (MARK2), a member of the
serine/threonine protein kinase family, phosphorylates microtubule-associated proteins …
serine/threonine protein kinase family, phosphorylates microtubule-associated proteins …
NUAKs promote mTOR/c-Myc-induced glucose and glutamine reprogramming for cell growth and metastasis in breast cancer cells
ASWW Raj, R Manoharan - Biochimica et Biophysica Acta (BBA)-Molecular …, 2025 - Elsevier
Breast cancer progression and metastasis are closely connected to changes in glucose and
glutamine metabolism. While Novel (nua) kinase family 1 (NUAK1) and Novel (nua) kinase …
glutamine metabolism. While Novel (nua) kinase family 1 (NUAK1) and Novel (nua) kinase …
[HTML][HTML] α-Tocotrienol Protects Neurons by Preventing Tau Hyperphosphorylation via Inhibiting Microtubule Affinity-Regulating Kinase Activation
Y Liu, Y Chen, K Fukui - International Journal of Molecular Sciences, 2024 - mdpi.com
In the pathological process of Alzheimer's disease, neuronal cell death is closely related to
the accumulation of reactive oxygen species. Our previous studies have found that oxidative …
the accumulation of reactive oxygen species. Our previous studies have found that oxidative …
[Retracted] Bioinformatics Method Was Used to Analyze the Highly Expressed Gene FAM83A of Breast Cancer in Young Women
Y Tang, H Wang, Q He, Y Chen… - Applied Bionics and …, 2022 - Wiley Online Library
Objectives. Preliminary analysis of breast cancer related to unknown functional gene
FAM83A through bioinformatics knowledge to inform further experimental studies. Select …
FAM83A through bioinformatics knowledge to inform further experimental studies. Select …