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MUTYH-associated polyposis (MAP)
The human mutY homologue (MUTYH) gene is responsible for inheritable polyposis and
colorectal cancer. This review discusses the molecular genetic aspects of the MUTYH gene …
colorectal cancer. This review discusses the molecular genetic aspects of the MUTYH gene …
TGF-β signaling alterations and colon cancer
Colorectal cancer is the second most common cause of cancer-related death in the United
States. Twin studies suggest that 35% of all colorectal cancer cases are inherited. High …
States. Twin studies suggest that 35% of all colorectal cancer cases are inherited. High …
Whole-genome landscape of pancreatic neuroendocrine tumours
The diagnosis of pancreatic neuroendocrine tumours (PanNETs) is increasing owing to
more sensitive detection methods, and this increase is creating challenges for clinical …
more sensitive detection methods, and this increase is creating challenges for clinical …
Clinical Implications of the Colorectal Cancer Risk Associated With MUTYH Mutation
Purpose Biallelic mutations in the base excision DNA repair gene MUTYH predispose to
colorectal cancer (CRC). Evidence that monoallelic mutations also confer an elevated CRC …
colorectal cancer (CRC). Evidence that monoallelic mutations also confer an elevated CRC …
Germline MutY human homologue mutations and colorectal cancer: a multisite case-control study
BACKGROUND & AIMS: The MutY human homologue (MYH) gene is a member of the base-
excision repair pathway involved in the repair of oxidative DNA damage. The objective of …
excision repair pathway involved in the repair of oxidative DNA damage. The objective of …
Association between biallelic and monoallelic germline MYH gene mutations and colorectal cancer risk
The MutY human homologue (MYH) gene encodes a member of the base excision repair
pathway that is involved in repairing oxidative damage to DNA. Two germline MYH gene …
pathway that is involved in repairing oxidative damage to DNA. Two germline MYH gene …
Risk of Colorectal Cancer in Monoallelic and Biallelic Carriers of MYH Mutations: A Population-Based Case-Family Study
Previous case-control studies have suggested that carriers of monoallelic germline
mutations in the MYH gene may be at increased risk of colorectal cancer. We applied a kin …
mutations in the MYH gene may be at increased risk of colorectal cancer. We applied a kin …
A large-scale meta-analysis to refine colorectal cancer risk estimates associated with MUTYH variants
Background: Defective DNA repair has a causal role in hereditary colorectal cancer (CRC).
Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated …
Defects in the base excision repair gene MUTYH are responsible for MUTYH-associated …
MUTYH-associated polyposis—from defect in base excision repair to clinical genetic testing
Established predisposition genes account for only a small proportion of familial colorectal
cancer. Recently, it has been shown that germline mutations in MUTYH predispose to …
cancer. Recently, it has been shown that germline mutations in MUTYH predispose to …
Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study
Background & Aims: Whereas it has conclusively been demonstrated that biallelic MutY
human homolog (MYH) mutations confer a significant risk for colorectal cancer (CRC), the …
human homolog (MYH) mutations confer a significant risk for colorectal cancer (CRC), the …