Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects
the survival of aerobic species and plays a prominent role in cardiovascular diseases. From …

Under conditions of hypoxia, most eukaryotic cells can shift their primary metabolic strategy
from predominantly mitochondrial respiration towards increased glycolysis to maintain ATP …

Many primary-tumor subregions have low levels of molecular oxygen, termed hypoxia.
Hypoxic tumors are at elevated risk for local failure and distant metastasis, but the molecular …

The purpose of this review is to summarize the research progress of PI3K/Akt signaling
pathway in erythropoiesis and glycolysis. Phosphatidylinositol‑4, 5‑bisphosphate 3‑kinase …

Hypoxia-inducible factors (HIFs) are master regulators of oxygen homeostasis that match O2
supply and demand for each of the 50 trillion cells in the adult human body. Cancer cells co …

Metastatic disease is the leading cause of cancer-related deaths and involves critical
interactions between tumor cells and the microenvironment. Hypoxia is a potent …

Introduction: Hypoxia is one of the intrinsic features of solid tumors, and it is always
associated with aggressive phenotypes, including resistance to radiation and …

Glioblastoma, a rare, and highly lethal form of brain cancer, poses significant challenges in
terms of therapeutic resistance, and poor survival rates for both adult and paediatric patients …

Of the deaths attributed to cancer, 90% are due to metastasis, and treatments that prevent or
cure metastasis remain elusive. Emerging data indicate that hypoxia and the extracellular …