The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …

Review of myeloperoxidase supporting optimal microbicidal activity in the phagosomes of
human neutrophils. Successful immune defense requires integration of multiple effector …

Epitranscriptomic modifications of mRNA are important regulators of gene expression. While
internal 2′-O-methylation (Nm) has been discovered on mRNA, questions remain about its …

This review provides a practical guide to myeloperoxidase (MPO) and presents to the reader
the diversity of its presence in biology. The review provides a historical background, from …

Collagen IV comprises the predominant protein network of basement membranes, a
specialized extracellular matrix, which underlie epithelia and endothelia. These networks …

Heme peroxidases are a major source of reactive oxidants at sites of inflammation in
biological systems. The formation of some of these oxidants (eg hypochlorous acid, HOCl) is …

The versatile clinical manifestations of the Hashimoto's chronic autoimmune thyroiditis often
include psycho-neurological disorders. Although hypothyroidism disturbs significantly the …

Peroxidasin is a heme-containing peroxidase enzyme that plays a vital role in the cross-
linking of collagen IV molecules in basement membranes. Collagen IV cross-links are …

The epithelium is a first line of defense against microorganisms in the gut. Reactive oxygen
species (ROS) have an important role in controlling the normal gut microbiota and …