RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …

Segmented RNA viruses are widespread in nature and include important human, animal
and plant pathogens, such as influenza viruses and rotaviruses. Although the origin of RNA …

RNA viruses induce the formation of subcellular organelles that provide microenvironments
conducive to their replication. Here we show that replication factories of rotaviruses …

Recent advances of rotavirus (RV) basic and applied research are reviewed. They consist of
determination of the RV particle structure and functions of structural proteins, classification …

Rotavirus assembly is a complex process that involves the stepwise acquisition of protein
layers in distinct intracellular locations to form the fully assembled particle. Understanding …

The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that
includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral …

Numerous interventions are in clinical development for respiratory syncytial virus (RSV)
infection, including small molecules that target viral transcription and replication. These …

Since its discovery 40 years ago, rotavirus (RV) is considered to be a major cause of infant
and childhood morbidity and mortality particularly in develo** countries. Nearly every …

Viral replication is rapid and robust, but it is far from a chaotic process. Instead, successful
production of infectious progeny requires that events occur in the correct place and at the …

Rotaviruses (RVs) are a large genetically diverse population of segmented double-stranded
(ds) RNA viruses that are important causes of gastroenteritis in many animal species. The …