Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

Abstract Treatment options for patients with metastatic melanoma, and especially BRAF-
mutant melanoma, have changed dramatically in the past 5 years, with the FDA approval of …

Simple Summary Patients with advanced melanoma are often treated with v-raf murine
sarcoma viral oncogene homolog B1 (BRAF) inhibitors. Although these agents prolong life …

Aberrant NLRP3 inflammasome activation contributes to the development of endotoxemia.
The importance of negative regulation of NLRP3 inflammasomes remains poorly …

African swine fever virus (ASFV) is a large DNA virus that is highly contagious and
pathogenic in domestic pigs with a mortality rate up to 100%. However, how ASFV …

Opinion statement Melanoma is caused by a variety of somatic mutations, and among these
mutations, BRAF mutation occurs most frequently and has routinely been evaluated as a …

Melanoma is a most dangerous and deadly type of skin cancer, and considered intrinsically
resistant to both radiotherapy and chemotherapy. It has become a major public health …

Targeted therapy and immunotherapy have greatly improved the prognosis of patients with
metastatic melanoma, but resistance to these therapeutic modalities limits the percentage of …

Melanoma is an aggressive malignancy of melanocytes and most commonly arises in the
skin. In 2002, BRAF gene mutations were identified in melanoma, and this finding resulted in …

Circular RNAs are known to regulate the biological processes of hepatocellular carcinoma
(HCC), and humans with Down syndrome are at low risk of develo** solid tumors due to …