Diabetes mellitus and associated chronic hyperglycemia enhance the risk of acute ischemic
stroke and lead to worsened clinical outcome and increased mortality. However, post-stroke …

Independent of its role in energy metabolism, glucose is also required for both quenching
and production of reactive oxygen species in the central nervous system. This stems from …

Importance Treatment with remote ischemic perconditioning has been reported to reduce
brain infarction volume in animal models of stroke. Whether this neuroprotective effect was …

Abstract Background and Aims Stress hyperglycemia is frequent in patients with acute
ischemic stroke. However, it is unclear whether stress hyperglycemia only reflects stroke …

Background and Purpose—Sparse data are available regarding the association between
hyperglycemia and outcomes in acute ischemic stroke patients receiving mechanical …

Objective A study was undertaken to test in a subgroup reanalysis of the URICO‐ICTUS trial
whether uric acid is superior to placebo in improving the functional outcome in patients with …

Background and Aims: A potential strategy to treat ischemic stroke may be the application of
repeated remote ischemic postconditioning (rIPostC). This consists of several cycles of brief …

Background and Purpose—Intensive insulin therapy (IIT) has not yet proven its efficacy on
stroke prognosis or in the reduction of MRI infarct growth. The INSULINFARCT study aims at …

Hyperglycemia (HG), a common phenomenon in all types of acute strokes, is increasingly
considered as a potential therapeutic target in ischemic stroke because there is now strong …

Abstract Immune-inflammatory, metabolic, oxidative, and nitrosative stress (IMO&NS)
pathways and, consequently, neurotoxicity are involved in acute ischemic stroke (IS). The …