Understanding mechanisms of antioxidant action in health and disease

B Halliwell - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Several different reactive oxygen species (ROS) are generated in vivo. They have roles in
the development of certain human diseases whilst also performing physiological functions …

Several lines of antioxidant defense against oxidative stress: Antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight …

K Jomova, SY Alomar, SH Alwasel, E Nepovimova… - Archives of …, 2024 - Springer
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for
playing a dual role, since they can be either deleterious or beneficial to biological systems …

GPX4 in cell death, autophagy, and disease

Y **e, R Kang, DJ Klionsky, D Tang - Autophagy, 2023 - Taylor & Francis
ABSTRACT Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX
(phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use …

Research progress of glutathione peroxidase family (GPX) in redoxidation

J Pei, X Pan, G Wei, Y Hua - Frontiers in pharmacology, 2023 - frontiersin.org
Maintaining the balance of a cell's redox function is key to determining cell fate. In the critical
redox system of mammalian cells, glutathione peroxidase (GPX) is the most prominent …

[HTML][HTML] A review on selenium nanoparticles and their biomedical applications

KK Karthik, BV Cheriyan, S Rajeshkumar… - Biomedical …, 2024 - Elsevier
Nanotechnology has enormous promise for a wide range of applications in biology.
Nanoparticles (NPs) have the benefit of improving bioactivity, decreasing toxicity, allowing …

Selenium, iodine and iron–essential trace elements for thyroid hormone synthesis and metabolism

J Köhrle - International journal of molecular sciences, 2023 - mdpi.com
The adequate availability and metabolism of three essential trace elements, iodine,
selenium and iron, provide the basic requirements for the function and action of the thyroid …

[HTML][HTML] Hexavalent-chromium-induced oxidative stress and the protective role of antioxidants against cellular toxicity

V Singh, N Singh, M Verma, R Kamal, R Tiwari… - Antioxidants, 2022 - mdpi.com
Hexavalent chromium is a highly soluble environmental contaminant. It is a widespread
anthropogenic chromium species that is 100 times more toxic than trivalent chromium …

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Q Yan, S Liu, Y Sun, C Chen, S Yang, M Lin… - Journal of translational …, 2023 - Springer
Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …

[HTML][HTML] Oxidative stress in healthy and pathological red blood cells

F Orrico, S Laurance, AC Lopez, SD Lefevre… - Biomolecules, 2023 - mdpi.com
Red cell diseases encompass a group of inherited or acquired erythrocyte disorders that
affect the structure, function, or production of red blood cells (RBCs). These disorders can …

Antioxidant metabolism pathways in vitamins, polyphenols, and selenium: parallels and divergences

CMC Andrés, JM Pérez de la Lastra, CA Juan… - International Journal of …, 2024 - mdpi.com
Free radicals (FRs) are unstable molecules that cause reactive stress (RS), an imbalance
between reactive oxygen and nitrogen species in the body and its ability to neutralize them …