Phosphonate biochemistry

GP Horsman, DL Zechel - Chemical reviews, 2017 - ACS Publications
Organophosphonic acids are unique as natural products in terms of stability and mimicry.
The C–P bond that defines these compounds resists hydrolytic cleavage, while the …

Utilization of glyphosate as phosphate source: biochemistry and genetics of bacterial carbon-phosphorus lyase

B Hove-Jensen, DL Zechel… - … and Molecular Biology …, 2014 - Am Soc Microbiol
After several decades of use of glyphosate, the active ingredient in weed killers such as
Roundup, in fields, forests, and gardens, the biochemical pathway of transformation of …

PCycDB: a comprehensive and accurate database for fast analysis of phosphorus cycling genes

J Zeng, Q Tu, X Yu, L Qian, C Wang, L Shu, F Liu, S Liu… - Microbiome, 2022 - Springer
Background Phosphorus (P) is one of the most essential macronutrients on the planet, and
microorganisms (including bacteria and archaea) play a key role in P cycling in all living …

Organophosphonates revealed: new insights into the microbial metabolism of ancient molecules

JW McGrath, JP Chin, JP Quinn - Nature Reviews Microbiology, 2013 - nature.com
Organophosphonates are ancient molecules that contain the chemically stable C–P bond,
which is considered a relic of the reducing atmosphere on primitive earth. Synthetic …

Molecular Mechanisms of Phosphate Sensing, Transport and Signalling in Streptomyces and Related Actinobacteria

JF Martín, P Liras - International journal of molecular sciences, 2021 - mdpi.com
Phosphorous, in the form of phosphate, is a key element in the nutrition of all living beings.
In nature, it is present in the form of phosphate salts, organophosphates, and phosphonates …

Mycobacterial dormancy systems and host responses in tuberculosis

V Peddireddy, SN Doddam, N Ahmed - Frontiers in immunology, 2017 - frontiersin.org
Tuberculosis (TB) caused by the intracellular pathogen, Mycobacterium tuberculosis (Mtb),
claims more than 1.5 million lives worldwide annually. Despite promulgation of multipronged …

Physiology of mycobacteria

GM Cook, M Berney, S Gebhard, M Heinemann… - Advances in microbial …, 2009 - Elsevier
Mycobacterium tuberculosis is a prototrophic, metabolically flexible bacterium that has
achieved a spread in the human population that is unmatched by any other bacterial …

The genes and enzymes of phosphonate metabolism by bacteria, and their distribution in the marine environment

JF Villarreal-Chiu, JP Quinn, JW McGrath - Frontiers in microbiology, 2012 - frontiersin.org
Phosphonates are compounds that contain the chemically stable carbon–phosphorus (C–P)
bond. They are widely distributed amongst more primitive life forms including many marine …

Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions

T Eitinger, DA Rodionov, M Grote… - FEMS microbiology …, 2011 - academic.oup.com
Since their discovery in the 1960s as 'osmotic shock-sensitive'transporters, a plethora of so-
called binding protein-dependent (canonical) ATP-binding cassette (ABC) importers has …

Adaptation to environmental stimuli within the host: two-component signal transduction systems of Mycobacterium tuberculosis

DJ Bretl, C Demetriadou, TC Zahrt - Microbiology and molecular …, 2011 - Am Soc Microbiol
Pathogenic microorganisms encounter a variety of environmental stresses following
infection of their respective hosts. Mycobacterium tuberculosis, the etiological agent of …