Bacterial infections represent a significant health threat globally, and are responsible for the
majority of hospital-acquired infections, leading to extensive mortality and burden on global …

Gram-positive bacteria are responsible for a broad range of infectious diseases, and the
emergency and wide spread of drug-resistant Gram-positive pathogens including MRSA …

In the current practices of antiinfective therapy, ciprofloxacin is a very popular
fluoroquinolone having a broad spectrum of activity and diverse therapeutic prospects. The …

Piperazine is one of the most sought heterocyclics for the development of new drug
candidates. This ring can be traced in a number of well established, commercially available …

Fluoroquinolones are one of the most promising and vigorously pursued areas of
contemporary antiinfective chemotherapy depicting broad spectrum and potent activity. They …

Escherichia coli (E. coli) is the most common pathogen in both hospital and community
settings, and is capable of causing infections that can lead to serious consequences …

A series of novel 1, 2, 4-triazole-ciprofloxacin hybrids was designed, synthesised and
evaluated in vitro against drug-susceptible and drug-resistant bacteria. A significant part of …

A series of clinafloxacin triazole hybrids as a new type of antibacterial and antifungal agents
were synthesized for the first time and screened for their antimicrobial efficacy against four …

As we are interested in synthetizing biologically active leads with dual anticancer and
antibacterial activity, we adopted biology oriented drug synthesis (BIODS) strategy to …

A series of new bis-1, 2, 3-triazole linked ciprofloxacin conjugates was designed,
synthesized and evaluated in vitro antibacterial activity against a panel of clinically relevant …