Antidote-mediated reversal of extracellular aptamer staining

B Sullenger, B Gray, M Nichols - US Patent 11,634,772, 2023 - Google Patents
Provided herein are compositions and methods for sorting and/or identifying live cells. The
compositions and methods provide for staining of live cells with aptamer so particular cells …

Von Willebrand Factor (VWF)-targeting agents and methods of using the same

SM Nimjee, B Sullenger, GA Pitoc, J Layzer - US Patent 11,965,160, 2024 - Google Patents
US11965160B2 - Von Willebrand Factor (VWF)-targeting agents and methods of using the
same - Google Patents US11965160B2 - Von Willebrand Factor (VWF)-targeting agents …

Von Willebrand Factor (VWF)—targeting agents and methods of using the same

SM Nimjee, GA Pitoc, J Layzer, B Sullenger - US Patent 10,889,816, 2021 - Google Patents
Provided herein are aptamers capable of inhibiting the activity of Von Willebrand Factor
(VWF). Pharmaceutical compositions comprising these aptamers are also provided …

Thrombus imaging aptamers and methods of using same

BA Sullenger, KAC Steen-Burrell, BP Gray - US Patent 11,565,002, 2023 - Google Patents
Provided herein are imaging agents, antidotes to the imaging agents and methods of using
the same to image a thrombus or blood clot or thrombin including sites of thrombin …