Steroid hormones regulate various physiological processes including development,
reproduction, and metabolism. These regulatory molecules are synthesized from cholesterol …

Abnormal synthesis and metabolism of sex steroids is involved in the pathogenesis of
various human diseases, such as endometriosis and cancers arising from the breast and …

Supplementation with acetyl-l-carnitine (ALC) during in vitro maturation significantly
improves the rates of oocyte cleavage and morula and blastocyst formation in sheep and …

Radiotherapy is a well-known cause of premature ovarian failure (POF). Therefore, we
investigated the molecular influence of genistein (GEN) on the ovarian reserve of rats …

Context: Regulation of progesterone production in granulosa cells is important for normal
reproductive functions. Steroidogenic acute regulatory protein (StAR) is recognized as the …

One of the main causes of female infertility is a deregulated antral follicular atresia, a
process of which the underlying molecular mechanisms are largely unknown. Our objective …

The expression and function of bone morphogenetic protein 4 (BMP4) gene in bovine
cumulus cells (CCs) was investigated to reveal the mechanisms by which it regulated cell …

Bisphenol A (BPA) is a harmful endocrine disrupting compound that alters not only classical
cellular mechanisms but also epigenetic mechanisms. Evidence suggests that BPA-induced …

Cholesterol is a precursor to steroid hormones and can be obtained from serum LDL or de
novo synthesis in steroidogenic cells. Before luteinizing hormone (LH) surge-induced …

Abstract Estradiol (E2), one of the main steroid hormones secreted by the ovaries, plays an
important role in maintaining normal female reproductive function. Ovarian granulosa cells …