The origin and activities of IgA1-containing immune complexes in IgA nephropathy

B Knoppova, C Reily, N Maillard, DV Rizk… - Frontiers in …, 2016 - frontiersin.org
IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading
to end-stage renal disease, as there is no disease-specific therapy. IgAN is diagnosed from …

Peptidomics and proteomics based on CE‐MS as a robust tool in clinical application: The past, the present, and the future

A Latosinska, J Siwy, H Mischak, M Frantzi - Electrophoresis, 2019 - Wiley Online Library
Capillary electrophoresis combined with mass spectrometry (CE‐MS) has been used for
several years for the investigation of proteins and peptides as biomarkers for diagnosis and …

Urinary proteomics for early diagnosis in diabetic nephropathy

P Zürbig, G Jerums, P Hovind, RJ MacIsaac… - Diabetes, 2012 - Am Diabetes Assoc
Diabetic nephropathy (DN) is a progressive kidney disease, a well-known complication of
long-standing diabetes. DN is the most frequent reason for dialysis in many Western …

Technical aspects and inter-laboratory variability in native peptide profiling: The CE–MS experience

H Mischak, A Vlahou, JPA Ioannidis - Clinical biochemistry, 2013 - Elsevier
Mass spectrometry platforms have attracted a lot of interest in the last 2 decades as profiling
tools for native peptides and proteins with clinical potential. However, limitations associated …

Current state of the art for enhancing urine biomarker discovery

M Harpole, J Davis, V Espina - Expert review of Proteomics, 2016 - Taylor & Francis
Introduction: Urine is a highly desirable biospecimen for biomarker analysis because it can
be collected recurrently by non-invasive techniques, in relatively large volumes. Urine …

Reproducibility evaluation of urinary peptide detection using CE-MS

E Mavrogeorgis, H Mischak, A Latosinska, J Siwy… - Molecules, 2021 - mdpi.com
In recent years, capillary electrophoresis coupled to mass spectrometry (CE-MS) has been
increasingly applied in clinical research especially in the context of chronic and age …

Biomarker discovery in mass spectrometry‐based urinary proteomics

S Thomas, L Hao, WA Ricke, L Li - PROTEOMICS–Clinical …, 2016 - Wiley Online Library
Urinary proteomics has become one of the most attractive topics in disease biomarker
discovery. MS‐based proteomic analysis has advanced continuously and emerged as a …

Liquid biopsy biomarkers in bladder cancer: a current need for patient diagnosis and monitoring

I Lodewijk, M Dueñas, C Rubio… - International journal of …, 2018 - mdpi.com
Bladder Cancer (BC) represents a clinical and social challenge due to its high incidence
and recurrence rates, as well as the limited advances in effective disease management …

Clinical proteomic biomarkers: relevant issues on study design & technical considerations in biomarker development

M Frantzi, A Bhat, A Latosinska - Clinical and translational medicine, 2014 - Springer
Biomarker research is continuously expanding in the field of clinical proteomics. A
combination of different proteomic–based methodologies can be applied depending on the …

Multiple sclerosis biomarker discoveries by proteomics and metabolomics approaches

A Jafari, A Babajani, M Rezaei-Tavirani - Biomarker Insights, 2021 - journals.sagepub.com
Multiple sclerosis (MS) is an autoimmune inflammatory disorder of the central nervous
system (CNS) resulting in demyelination and axonal loss in the brain and spinal cord. The …