The NLRP3 inflammasome pathway: a review of mechanisms and inhibitors for the treatment of inflammatory diseases
The NLRP3 inflammasome is a multiprotein complex that plays a pivotal role in regulating
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
the innate immune system and inflammatory signaling. Upon activation by PAMPs and …
Therapeutic implications of caffeic acid in cancer and neurological diseases
Caffeic acid (CA) is found abundantly in fruits, vegetables, tea, coffee, oils, and more. CA
and its derivatives have been used for many centuries due to their natural healing and …
and its derivatives have been used for many centuries due to their natural healing and …
Inhibitory effects of glycopyrronium, formoterol, and budesonide on coronavirus HCoV-229E replication and cytokine production by primary cultures of human nasal …
M Yamaya, H Nishimura, X Deng, M Sugawara… - Respiratory …, 2020 - Elsevier
Abstract Background Coronavirus 229E (HCoV-229E), one of the causes of the common
cold, exacerbates chronic obstructive pulmonary disease (COPD) and bronchial asthma …
cold, exacerbates chronic obstructive pulmonary disease (COPD) and bronchial asthma …
[HTML][HTML] Molecular pathways involved in COVID-19 and potential pathway-based therapeutic targets
Deciphering the molecular downstream consequences of severe acute respiratory
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
syndrome coronavirus (SARS-CoV)− 2 infection is important for a greater understanding of …
Roles of NF-κB in cancer and inflammatory diseases and their therapeutic approaches
MH Park, JT Hong - Cells, 2016 - mdpi.com
Nuclear factor-κB (NF-κB) is a transcription factor that plays a crucial role in various
biological processes, including immune response, inflammation, cell growth and survival …
biological processes, including immune response, inflammation, cell growth and survival …
Targeting the STAT3 signaling pathway in cancer: role of synthetic and natural inhibitors
Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …
transcription factors that mediate intracellular signaling that is usually generated at cell …
Inflammation, a double-edge sword for cancer and other age-related diseases
Increasing evidence from diverse sources during the past several years has indicated that
long-term, low level, chronic inflammation mediates several chronic diseases including …
long-term, low level, chronic inflammation mediates several chronic diseases including …
Natural products can be used in therapeutic management of COVID-19: Probable mechanistic insights
The unexpected emergence of the new Coronavirus disease (COVID-19) has affected more
than three hundred million individuals and resulted in more than five million deaths …
than three hundred million individuals and resulted in more than five million deaths …
Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival
Severe acute respiratory syndrome coronavirus (SARS-CoV) is the etiological agent of a
respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV …
respiratory disease that has a 10% mortality rate. We previously showed that SARS-CoV …
Basic biochemical mechanisms behind the health benefits of polyphenols
Polyphenols and consequently many flavonoids have several beneficial actions on human
health. However, the actual molecular interactions of polyphenols with biological systems …
health. However, the actual molecular interactions of polyphenols with biological systems …