Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …

Human ageing is a complex, multifactorial process characterised by physiological damage,
increased risk of age-related diseases and inevitable functional deterioration. As the …

Background DNA methylation-derived epigenetic clocks and frailty are well-established
biological age measures capturing different aging processes. However, whether they are …

The notion of “biological aging” as distinct from chronological aging has been of increasing
interest in psychiatry, and many studies have explored associations of stress and psychiatric …

Adverse effects of low vitamin D level on mortality and morbidity are controversially
discussed. Especially older people are at risk for vitamin D deficiency and therefore exposed …

Abstract Background Patients with Type 2 diabetes mellitus (T2D) are at risk for micro-and
macrovascular complications. Implementable risk scores are needed to improve targeted …

Adverse effects of psychological stress on physical and mental health, especially in older
age, are well documented. How perceived stress relates to the epigenetic clock measure …

Physical activity (PA) has a substantial impact on health and mortality. Besides
questionnaires that rely on subjective assessment of activity levels, accelerometers can help …

Posttraumatic stress disorder (PTSD) is associated with mortality and increased risk of
diseases of aging, but underlying mechanisms remain unclear. We examine associations of …

Aging is associated with changes in the immune system, increased inflammation and
mitochondrial dysfunction. The relationship between these phenomena and the clinical …