New horizons for precision medicine in biliary tract cancers
JW Valle, A Lamarca, L Goyal, J Barriuso, AX Zhu - Cancer discovery, 2017 - AACR
Biliary tract cancers (BTC), including cholangiocarcinoma and gallbladder cancer, are poor-
prognosis and low-incidence cancers, although the incidence of intrahepatic …
prognosis and low-incidence cancers, although the incidence of intrahepatic …
[HTML][HTML] TGF-β signaling in liver, pancreas, and gastrointestinal diseases and cancer
Genetic alterations affecting transforming growth factor–β (TGF-β) signaling are
exceptionally common in diseases and cancers of the gastrointestinal system. As a regulator …
exceptionally common in diseases and cancers of the gastrointestinal system. As a regulator …
Pathogenesis, diagnosis, and management of cholangiocarcinoma
SI Ilyas, GJ Gores - Gastroenterology, 2013 - Elsevier
Cholangiocarcinomas (CCAs) are hepatobiliary cancers with features of cholangiocyte
differentiation; they can be classified anatomically as intrahepatic CCA (iCCA), perihilar …
differentiation; they can be classified anatomically as intrahepatic CCA (iCCA), perihilar …
Mutational landscape of intrahepatic cholangiocarcinoma
S Zou, J Li, H Zhou, C Frech, X Jiang, JSC Chu… - Nature …, 2014 - nature.com
Intrahepatic cholangiocarcinoma (ICC) is a fatal primary liver cancer (PLC) that affects 5–
10% of all PLCs. Here we sequence tumour and matching control sample pairs of a large …
10% of all PLCs. Here we sequence tumour and matching control sample pairs of a large …
[HTML][HTML] The role of TGF-β/SMAD4 signaling in cancer
Transforming growth factor β (TGF-β) signaling pathway plays important roles in many
biological processes, including cell growth, differentiation, apoptosis, migration, as well as …
biological processes, including cell growth, differentiation, apoptosis, migration, as well as …
The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals
The conserved Hippo signaling pathway regulates organ size in Drosophila and mammals.
While a core kinase cascade leading from the protein kinase Hippo (Hpo)(Mst1 and Mst2 in …
While a core kinase cascade leading from the protein kinase Hippo (Hpo)(Mst1 and Mst2 in …
Exome sequencing of liver fluke–associated cholangiocarcinoma
CK Ong, C Subimerb, C Pairojkul, S Wongkham… - Nature …, 2012 - nature.com
Opisthorchis viverrini–related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major
public health concern in areas endemic for this parasite. We report here whole-exome …
public health concern in areas endemic for this parasite. We report here whole-exome …
[HTML][HTML] Hydrodynamic transfection for generation of novel mouse models for liver cancer research
X Chen, DF Calvisi - The American journal of pathology, 2014 - Elsevier
Primary liver cancers, including hepatocellular carcinoma and intrahepatic
cholangiocarcinoma, are leading causes of cancer-related death worldwide. Recent large …
cholangiocarcinoma, are leading causes of cancer-related death worldwide. Recent large …
Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration
Y Malato, S Naqvi, N Schürmann, R Ng… - The Journal of …, 2011 - Am Soc Clin Investig
Recent evidence has contradicted the prevailing view that homeostasis and regeneration of
the adult liver are mediated by self duplication of lineage-restricted hepatocytes and biliary …
the adult liver are mediated by self duplication of lineage-restricted hepatocytes and biliary …
[PDF][PDF] Cholangiocarcinoma: advances in pathogenesis, diagnosis, and treatment
B Blechacz, GJ Gores - Hepatology, 2008 - Wiley Online Library
Cholangiocarcinoma (CCA) is an epithelial can-cer originating from the bile ducts with
features of cholangiocyte differentiation. 1 CCA is the second most common primary hepatic …
features of cholangiocyte differentiation. 1 CCA is the second most common primary hepatic …