Understanding the aspects of cell functionality that account for disease mechanisms or drug
modes of action is a main challenge for precision medicine. Classical gene-based …

Babelomics has been running for more than one decade offering a user-friendly interface for
the functional analysis of gene expression and genomic data. Here we present its fifth …

Understanding the aspects of the cell functionality that account for disease or drug action
mechanisms is a main challenge for precision medicine. Here we propose a new method …

Simple Summary The use of diverse omics platforms and small sample sizes in current
studies of cancer chemoresistance limits consensus regarding the molecular mechanisms …

Background Understanding the aspects of the cell functionality that account for disease or
drug action mechanisms is one of the main challenges in the analysis of genomic data and …

Metabolic reprogramming plays an important role in cancer development and progression
and is a well-established hallmark of cancer. Despite its inherent complexity, cellular …

Many complex traits, as drug response, are associated with changes in biological pathways
rather than being caused by single gene alterations. Here, a predictive framework is …

In spite of the increasing availability of genomic and transcriptomic data, there is still a gap
between the detection of perturbations in gene expression and the understanding of their …

The sustained generation of genomic data in the last decade has increased the knowledge
on the causal mutations of a large number of diseases, especially for highly penetrant …

The discovery of actionable targets is crucial for targeted therapies and is also a constituent
part of the drug discovery process. The success of an intervention over a target depends …