The mammalian mitochondrial electron transport chain (ETC) includes complexes I‑IV, as
well as the electron transporters ubiquinone and cytochrome c. There are two electron …

Redox reactions play important roles in almost all biological processes, including
photosynthesis and respiration, which are two essential energy processes that sustain all life …

Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of
human diseases. Identifying all of the proteins resident in this organelle and understanding …

Mitochondrial disorders are among the most frequent inborn errors of metabolism, their
primary cause being the dysfunction of the oxidative phosphorylation system (OXPHOS) …

Reductions in the blood supply produce considerable injury if the duration of ischemia is
prolonged. Paradoxically, restoration of perfusion to ischemic organs can exacerbate tissue …

Complex I is the first and largest enzyme of the respiratory chain and has a central role in
cellular energy production through the coupling of NADH: ubiquinone electron transfer to …

Complex I (NADH: ubiquinone oxidoreductase) is crucial for respiration in many aerobic
organisms. In mitochondria, it oxidizes NADH from the tricarboxylic acid cycle and β …

Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of
disease and redox signaling in the cardiovascular system. Under basal or pathological …

Oxidative damage from elevated production of reactive oxygen species (ROS) contributes to
ischemia-reperfusion injury in myocardial infarction and stroke. The mechanism by which …

The assembly of the five oxidative phosphorylation system (OXPHOS) complexes in the
inner mitochondrial membrane is an intricate process. The human enzymes comprise core …