Subcellular structure, heterogeneity, and plasticity of senescent cells

TC Bitencourt, JE Vargas, AO Silva, LR Fraga… - Aging …, 2024 - Wiley Online Library
Cellular senescence is a state of permanent growth arrest. It can be triggered by telomere
shortening (replicative senescence) or prematurely induced by stresses such as DNA …

[HTML][HTML] Beyond SAHF: an integrative view of chromatin compartmentalization during senescence

I Olan, T Handa, M Narita - Current Opinion in Cell Biology, 2023 - Elsevier
Cellular senescence, a persistent form of cell cycle arrest, has been linked to the formation
of heterochromatic foci, accompanied by additional concentric epigenetic layers. However …

The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review

DH Jang, JW Shin, E Shim, N Ohtani, OH Jeon - Aging Cell, 2024 - Wiley Online Library
The intricate interplay between cellular senescence and alterations in the gut microbiome
emerges as a pivotal axis in the aging process, increasingly recognized for its contribution to …

Increased PTCHD4 expression via m6A modification of PTCHD4 mRNA promotes senescent cell survival

M Rossi, N Banskota, CH Shin, C Anerillas… - Nucleic Acids …, 2024 - academic.oup.com
RNA modifications, including N6-methyladenosine (m6A), critically modulate protein
expression programs in a range of cellular processes. Although the transcriptomes of cells …

Intracellular acidification and glycolysis modulate inflammatory pathway in senescent cells

S Kawakami, Y Johmura… - The Journal of …, 2024 - academic.oup.com
Senescent cells accumulate in various organs with ageing, and its accumulation induces
chronic inflammation and age-related physiological dysfunctions. Several remodelling of …

Develo** transcriptomic signatures as a biomarker of cellular senescence

S Mahmud, LE Pitcher, E Torbenson… - Ageing Research …, 2024 - Elsevier
Cellular senescence is a cell fate driven by different types of stress, where damaged cells
exit from the cell cycle and, in many cases, develop an inflammatory senescence-associated …

Cardiomyocyte senescence and the potential therapeutic role of senolytics in the heart

P Zhai, J Sadoshima - The journal of cardiovascular aging, 2024 - pmc.ncbi.nlm.nih.gov
Cellular senescence in cardiomyocytes, characterized by cell cycle arrest, resistance to
apoptosis, and the senescence-associated secretory phenotype, occurs during aging and in …

Investigation of human aging at the single-cell level

Y Li, Q Wang, Y Xuan, J Zhao, J Li, Y Tian… - Ageing Research …, 2024 - Elsevier
Human aging is characterized by a gradual decline in physiological functions and an
increased susceptibility to various diseases. The complex mechanisms underlying human …

Increased ANKRD1 Levels in Early Senescence Mediated by RBMS1-Elicited ANKRD1 mRNA Stabilization

CH Shin, M Rossi, C Anerillas… - … and Cellular Biology, 2024 - Taylor & Francis
Cellular senescence is a dynamic biological process triggered by sublethal cell damage and
driven by specific changes in gene expression programs. We recently identified ANKRD1 …

Identification of senescent cell subpopulations by CITE‐seq analysis

K Abdelmohsen, K Mazan‐Mamczarz, R Munk… - Aging …, 2024 - Wiley Online Library
Cellular senescence, a state of persistent growth arrest, is closely associated with aging and
age‐related diseases. Deciphering the heterogeneity within senescent cell populations and …