Cancer is an abnormal state of cells where they undergo uncontrolled proliferation and
produce aggressive malignancies that causes millions of deaths every year. With the new …

Adenosine receptors (ARs) are widely acknowledged pharmacological targets yet are still
underutilized in clinical practice. Their ubiquitous distribution in almost all cells and tissues …

Abstract ATPase Inhibitory Factor 1 (IF1) regulates the activity of mitochondrial ATP
synthase. The expression of IF1 in differentiated human and mouse cells is highly variable …

Physical exercise represents an effective preventive and therapeutic strategy beneficially
modifying the course of multiple diseases. The protective mechanisms of exercise are …

Introduction The last decade has led to rapid developments and increased usage of
computational tools at the single-cell level. However, our knowledge remains limited in how …

Sinomenine is an active substance extracted from the traditional Chinese medicine
Sinomenium acutum. Sinomenine has been shown to mediate a wide range of …

A3 adenosine receptor (A3AR) positive allosteric modulators (PAMs)(2, 4-disubstituted-1 H-
imidazo [4, 5-c] quinolin-4-amines) allosterically increase the E max of A3AR agonists, but …

Migraine is a primary headache disorder, which is an enormous burden to the healthcare
system. While some aspects of the pathomechanism of migraines remain unknown, the most …

The modulation of the A2B adenosine receptor is a promising strategy in cancer (immuno)
therapy, with A2BAR antagonists emerging as immune checkpoint inhibitors. Herein, we …

Chronic pain has a debilitating consequences on health and lifestyle. The currently
available analgesics are often ineffective and accompanied by undesirable adverse effects …