Summary Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …

Creutzfeldt–Jakob disease (CJD) is a rapidly progressive, fatal and transmissible
neurodegenerative disease associated with the accumulation of misfolded prion protein in …

The clinical diagnosis of synucleinopathies, including Parkinson's disease (PD), dementia
with Lewy bodies (DLB), and multiple system atrophy (MSA), is challenging, especially at an …

Background and Objectives Real-time quaking-induced conversion (RT-QuIC) assay detects
misfolded α-synuclein (AS) in the skin and CSF of patients with the synucleinopathies …

Background Evidence suggests that skin represents a suitable matrix for demonstrating α‐
synuclein oligomers as a diagnostic biomarker for Lewy body disease. Objective The …

Prion diseases are fatal neurodegenerative disorders with known natural occurrence in
humans and a few other mammalian species. The diseases are experimentally …

Background Tauopathies are a group of age-related neurodegenerative diseases
characterized by the accumulation of pathologically hyperphosphorylated tau protein in the …

Tissue accumulation of abnormal aggregates of amyloidogenic proteins such as prion
protein, α-synuclein, and tau represents the hallmark of most common neurodegenerative …

Efforts to contain the spread of chronic wasting disease (CWD), a fatal, contagious prion
disease of cervids, would be aided by the availability of additional diagnostic tools. RT-QuIC …

Importance Recent studies have revealed that autopsy skin samples from cadavers with
prion diseases (PRDs) exhibited a positive prion seeding activity similar to cerebrospinal …