Roles of axon guidance molecules in neuronal wiring in the develo** spinal cord

A Chédotal - Nature Reviews Neuroscience, 2019 - nature.com
The spinal cord receives, relays and processes sensory information from the periphery and
integrates this information with descending inputs from supraspinal centres to elicit precise …

New genetics in congenital hypothyroidism

A Stoupa, D Kariyawasam, M Muzza, T de Filippis… - Endocrine, 2021 - Springer
Introduction Congenital hypothyroidism (CH) is the most frequent neonatal endocrine
disorder and one of the most common preventable forms of mental retardation worldwide …

Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control

S Schlienger, PT Yam, N Balekoglu, H Ducuing… - Science …, 2023 - science.org
Mirror movements (MM) disorder is characterized by involuntary movements on one side of
the body that mirror intentional movements on the opposite side. We performed genetic …

Mitochondrial dysfunction as a target in spinal cord injury: intimate correlation between pathological processes and therapeutic approaches

J Schmidt, HR Quintá - Neural regeneration research, 2023 - journals.lww.com
Traumatic spinal cord injuries interrupt the connection of all axonal projections with their
neuronal targets below and above the lesion site. This interruption results in either …

Neurogenesis, neuronal migration, and axon guidance

A Accogli, N Addour-Boudrahem, M Srour - Handbook of clinical neurology, 2020 - Elsevier
Abstract Development of the central nervous system (CNS) is a complex, dynamic process
that involves a precisely orchestrated sequence of genetic, environmental, biochemical, and …

Insights from the neural guidance factor Netrin-1 into neurodegeneration and other diseases

M Cai, Q Zheng, Y Chen, S Liu, H Zhu… - Frontiers in Molecular …, 2024 - frontiersin.org
Netrin-1 was initially discovered as a neuronal growth cue for axonal guidance, and its
functions have later been identified in inflammation, tumorigenesis, neurodegeneration, and …

Involvement of netrins and their receptors in neuronal migration in the cerebral cortex

S Yamagishi, Y Bando, K Sato - Frontiers in cell and developmental …, 2021 - frontiersin.org
In mammals, excitatory cortical neurons develop from the proliferative epithelium and
progenitor cells in the ventricular zone and subventricular zone, and migrate radially to the …

DCC mutation update: Congenital mirror movements, isolated agenesis of the corpus callosum, and developmental split brain syndrome

APL Marsh, TJ Edwards, C Galea, HM Cooper… - Human …, 2018 - Wiley Online Library
The deleted in colorectal cancer (DCC) gene encodes the netrin‐1 (NTN1) receptor DCC, a
transmembrane protein required for the guidance of commissural axons. Germline DCC …

Genetics of congenital hypothyroidism: Modern concepts

A Stoupa, D Kariyawasam, M Polak, A Carré - Pediatric Investigation, 2022 - mednexus.org
Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder and one
of the most common preventable causes of intellectual disability in the world. CH may be …

Commissural axon guidance in the develo** spinal cord: from Cajal to the present day

JD Comer, S Alvarez, SJ Butler, JA Kaltschmidt - Neural Development, 2019 - Springer
During neuronal development, the formation of neural circuits requires develo** axons to
traverse a diverse cellular and molecular environment to establish synaptic contacts with the …