[HTML][HTML] The mechanism of action of N-acetylcysteine (NAC): The emerging role of H2S and sulfane sulfur species
Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …
(NAC) is the standard of care to treat paracetamol intoxication, and is included on the World …
N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why
The main molecular mechanisms explaining the well-established antioxidant and reducing
activity of N-acetylcysteine (NAC), the N-acetyl derivative of the natural amino acid l …
activity of N-acetylcysteine (NAC), the N-acetyl derivative of the natural amino acid l …
Ferroptotic mechanisms and therapeutic targeting of iron metabolism and lipid peroxidation in the kidney
Ferroptosis is a mechanism of regulated necrotic cell death characterized by iron-
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …
dependent, lipid peroxidation-driven membrane destruction that can be inhibited by …
[HTML][HTML] Recent developments in essentiality of trivalent chromium and toxicity of hexavalent chromium: implications on human health and remediation strategies
Among the many heavy metals, chromium (Cr) is one of the fascinating ones. In its two most
prevalent oxidation forms, trivalent (Cr 3+) and hexavalent (Cr 6+), Cr has completely …
prevalent oxidation forms, trivalent (Cr 3+) and hexavalent (Cr 6+), Cr has completely …
Antioxidants can increase melanoma metastasis in mice
Antioxidants in the diet and supplements are widely used to protect against cancer, but
clinical trials with antioxidants do not support this concept. Some trials show that …
clinical trials with antioxidants do not support this concept. Some trials show that …
Existing and potential therapeutic uses for N-acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits
Abstract N-acetyl-l-cysteine (NAC) has long been used therapeutically for the treatment of
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …
acetaminophen (paracetamol) overdose, acting as a precursor for the substrate (l-cysteine) …
[HTML][HTML] The multifaceted therapeutic role of N-acetylcysteine (NAC) in disorders characterized by oxidative stress
Oxidative stress, which results in the damage of diverse biological molecules, is a ubiquitous
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …
cellular process implicated in the etiology of many illnesses. The sulfhydryl-containing …
N-acetyl cysteine functions as a fast-acting antioxidant by triggering intracellular H2S and sulfane sulfur production
The cysteine prodrug N-acetyl cysteine (NAC) is widely used as a pharmacological
antioxidant and cytoprotectant. It has been reported to lower endogenous oxidant levels and …
antioxidant and cytoprotectant. It has been reported to lower endogenous oxidant levels and …
Absence of Dystrophin Disrupts Skeletal Muscle Signaling: Roles of Ca2+, Reactive Oxygen Species, and Nitric Oxide in the Development of Muscular Dystrophy
DG Allen, NP Whitehead… - Physiological …, 2016 - journals.physiology.org
Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …
Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases
N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific
interest for decades due to its important medical applications. It also represents a nutritional …
interest for decades due to its important medical applications. It also represents a nutritional …