The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …

Nuclear factor erythroid 2-related factor 2 (Nrf2), a transcription factor that regulates redox
homeostasis, plays a pivotal role in several cellular processes such as cell proliferation and …

Persistent symptoms of COVID-19 survivors constitute long COVID syndrome, also called
post-acute sequelae of SARS-CoV-2 infection (PASC). Neurologic manifestations of PASC …

Acinar cell injury and the inflammatory response are critical bioprocesses of acute
pancreatitis (AP). We investigated the role and underlying mechanism of sulfiredoxin-1 …

Abstract Sulfiredoxin 1 (SRXN1) is a pivotal regulator of the antioxidant response in
eukaryotic cells. However, the role of SRXN1 in hepatocellular carcinoma (HCC) is far from …

Sedanolide is a bioactive compound with anti-inflammatory and antitumor activities.
Although it has been recently suggested that sedanolide activates the nuclear factor E2 …

Cerebral cavernous malformations (CCM) are lesions affecting brain capillaries that appear
with a mulberry-like morphology. This shape results from the enlarged and tangled …

Ferroptosis, a recently identified non-apoptotic form of cell death, is strongly associated with
neurological diseases and has emerged as a potential therapeutic target. Nevertheless, the …

Abstract Dexmedetomidine (Dex), an α2‐adrenergic receptor (α2‐AR) agonist, possesses
cardioprotection against ischemic/hypoxic injury, but the exact mechanism is not fully …

Sulfur mustard (SM) and nitrogen mustard (NM) are vesicant agents that cause skin injury
and blistering through complicated cellular events, involving DNA damage, free radical …