Protamine protects against vancomycin-induced kidney injury
J Shiau, P Engel, M Olsen, G Pais… - Antimicrobial Agents …, 2025 - journals.asm.org
Vancomycin causes kidney injury by accumulating in the proximal tubule, likely mediated by
megalin uptake. Protamine is a putative megalin inhibitor that shares binding sites with …
megalin uptake. Protamine is a putative megalin inhibitor that shares binding sites with …
[HTML][HTML] Comparison of Piperacillin-tazobactam and Vancomycin (TZP-VAN) with Piperacillin-tazobactam and Teicoplanin (TZP-TEI) for the risk of Acute Kidney Injury …
Objectives Both vancomycin (VAN) and teicoplanin (TEI) augment the risk of acute kidney
injury (AKI) when combined with piperacillin-tazobactam (TZP). We aimed to compare the …
injury (AKI) when combined with piperacillin-tazobactam (TZP). We aimed to compare the …
Impact of humanized vancomycin infusion on kidney function and kidney injury in a translational rat model
Allometric dose scaling aims to create isometric exposures between animals and humans
and is often employed in preclinical pharmacokinetic/pharmacodynamic models. Bolus …
and is often employed in preclinical pharmacokinetic/pharmacodynamic models. Bolus …
Nut cracked? Does the ACORN trial end the debate surrounding vancomycin and piperacillin-tazobactam combination therapy and increased risk for acute kidney …
Observational data published over the past decade have suggested that concomitant receipt
of piperacillin-tazobactam with vancomycin significantly increases the risk for vancomycin …
of piperacillin-tazobactam with vancomycin significantly increases the risk for vancomycin …