Cellular responses to DNA damage are important determinants of both cancer development
and cancer outcome following radiation therapy and chemotherapy. Identification of …

Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …

Despite the frequent use of ionising radiation (IR) in therapy and diagnostics and the
unavoidable exposure to external radiation sources, our knowledge regarding the …

Glioblastoma multiforme (GBM) is a highly malignant primary brain cancer with a dreadful
overall survival and for which treatment options are limited. Recent breakthroughs in novel …

Colorectal cancer (CRC) is one of the major tumor entities worldwide, with an increasing
incidence in younger people. CRC formation is causally linked to various genetic, life-style …

In this review we discuss the effects of exposure to complex PAH mixtures in vitro and in vivo
on mechanisms related to carcinogenesis. Of particular concern regarding exposure to …

The therapy of cancer emerged as multimodal treatment strategy. The major mode of action
of locally applied radiotherapy (RT) is the induction of DNA damage that triggers a network …

Malignant glioma, or glioblastoma, is the most common and lethal form of brain tumor with a
median survival time of 15 months. The established therapeutic regimen includes a tripartite …

Regulatory T cells (Treg) play a pivotal role in the immune system since they inhibit the T cell
response. It is well known that cyclophosphamide applied at low dose is able to stimulate …

Chemotherapy, especially if prolonged, disrupts attention, working memory and speed of
processing in humans. Most cancer drugs that cross the blood–brain barrier also decrease …