Neuroinflammation and central sensitization in chronic and widespread pain
Chronic pain is maintained in part by central sensitization, a phenomenon of synaptic
plasticity and increased neuronal responsiveness in central pain pathways after painful …
plasticity and increased neuronal responsiveness in central pain pathways after painful …
[HTML][HTML] The interplay between cytokines, inflammation, and antioxidants: Mechanistic insights and therapeutic potentials of various antioxidants and anti-cytokine …
NK Bhol, MM Bhanjadeo, AK Singh, UC Dash… - Biomedicine & …, 2024 - Elsevier
Cytokines regulate immune responses essential for maintaining immune homeostasis, as
deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory …
deregulated cytokine signaling can lead to detrimental outcomes, including inflammatory …
Cytokines, inflammation, and pain
JM Zhang, J An - International anesthesiology clinics, 2007 - journals.lww.com
Inflammatory responses in the peripheral (PNS) and central nervous systems (CNS) play
key roles in the development and persistence of many pathologic pain states. 1 Certain …
key roles in the development and persistence of many pathologic pain states. 1 Certain …
Emerging targets in neuroinflammation-driven chronic pain
Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …
and have limited success in controlling disease progression. Accumulating evidence …
The neuropathic pain triad: neurons, immune cells and glia
J Scholz, CJ Woolf - Nature neuroscience, 2007 - nature.com
Nociceptive pain results from the detection of intense or noxious stimuli by specialized high-
threshold sensory neurons (nociceptors), a transfer of action potentials to the spinal cord …
threshold sensory neurons (nociceptors), a transfer of action potentials to the spinal cord …
GM-CSF in inflammation
JA Hamilton - Journal of Experimental Medicine, 2020 - rupress.org
Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …
than its original in vitro identification as an inducer of granulocyte and macrophage …
Role of the immune system in chronic pain
F Marchand, M Perretti, SB McMahon - Nature Reviews Neuroscience, 2005 - nature.com
During the past two decades, an important focus of pain research has been the study of
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …
chronic pain mechanisms, particularly the processes that lead to the abnormal sensitivity …
Breaking barriers to novel analgesic drug development
AS Yekkirala, DP Roberson, BP Bean… - Nature reviews Drug …, 2017 - nature.com
Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …
Molecular mechanism of diabetic neuropathy and its pharmacotherapeutic targets
Diabetic neuropathy is regarded as one of the most debilitating outcomes of diabetes
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
mellitus and may cause pain, decreased motility, and even amputation. Diabetic neuropathy …
Immune and inflammatory mechanisms in neuropathic pain
G Moalem, DJ Tracey - Brain research reviews, 2006 - Elsevier
Tissue damage, inflammation or injury of the nervous system may result in chronic
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …
neuropathic pain characterised by increased sensitivity to painful stimuli (hyperalgesia), the …