Genomic imprinting is illustrative of intergenerational epigenetic inheritance. The passage of
parental genomes into the embryo is accompanied by epigenetic modifications, resulting in …

Trophoblasts play a crucial role in embryo implantation and in interacting with the maternal
uterus. The trophoblast lineage develops into a substantial part of the placenta, a temporary …

Genomic imprinting regulates parental origin-dependent monoallelic gene expression. It is
mediated by either germline differential methylation of DNA (canonical imprinting) or oocyte …

Germline epigenetic programming, including genomic imprinting, substantially influences
offspring development. Polycomb Repressive Complex 2 (PRC2) plays an important role in …

Farrerol, a natural flavanone, promotes homologous recombination (HR) repair to improve
genome-editing efficiency, but the specific protein that farrerol directly targets to regulate HR …

ABSTRACT How maternal Ezh1 and Ezh2 function in H3K27 methylation in vivo in pre-
implantation embryos and during embryonic development is not clear. Here, we have …

Membrane transporters are proteins responsible for facilitating the movement of molecules
within biological membranes. They play a vital role in maintaining cellular homeostasis by …

Background Non-genetic disease inheritance and offspring phenotype are substantially
influenced by germline epigenetic programming, including genomic imprinting. Loss of …

Genomic imprinting is required for sexual reproduction and embryonic development of
mammals, in which, differentially methylated regions (DMRs) regulate the parent-specific …

Cloned mammals can be achieved through somatic cell nuclear transfer (SCNT), which
involves reprogramming of differentiated somatic cells into a totipotent state. However, low …