LNK is a member of the SH2B family of adaptor proteins and is a non-redundant regulator of
cytokine signalling. Cytokines are secreted intercellular messengers that bind to specific …

Background: High blood pressure (BP) is a risk factor for cardiovascular morbidity and
mortality. While BP is regulated by the function of kidney, vasculature, and sympathetic …

Scientific reductionism has been the basis of disease classification and understanding for
more than a century. However, the reductionist approach of characterizing diseases from a …

Kidney disease associated with chronic cadmium (Cd) exposure is primarily due to proximal
tubule cell damage. This results in a sustained decline in glomerular filtration rate (GFR) and …

Hypertension (HT) is a modifiable risk factor for life-threatening cardiovascular diseases
(CVDs) including coronary artery disease, heart failure, or stroke. Despite significant …

The most common causes of chronic kidney disease, diabetes, and hypertension are
significant public health issues worldwide. Exposure to the heavy metal pollutant, cadmium …

Background: Hypertension is the commonest cardiovascular risk factor and a leading cause
of death worldwide. Several genetic variants are known to be involved in the pathogenesis …

At the dawn of the new decade, it is judicious to reflect on the boom of knowledge about
polygenic risk for essential hypertension supplied by the wealth of genome-wide association …

Exposure to low-dose environmental pollutant cadmium (Cd) increases the risks of both
albuminuria and hypertension by mechanisms which are poorly understood. Here, multiple …

Background It is valuable to analyze the genome-wide association studies (GWAS) data for
a complex disease phenotype in the context of the protein–protein interaction (PPI) network …