The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Traditionally, lymphocytic interferon γ (IFN-γ) was considered to be a simple'booster'of
proinflammatory responses by microglia (brain-resident macrophages) during bacterial or …

Tau-mediated neurodegeneration is a hallmark of Alzheimer's disease. Primary tauopathies
are characterized by pathological tau accumulation and neuronal and synaptic loss …

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …

Traumatic brain injury (TBI) and Alzheimer's disease (AD) represent 2 of the largest sources
of death and disability in the United States. Recent studies have identified TBI as a potential …

Physical exercise is well known as a non-pharmacological and holistic therapy believed to
prevent and mitigate numerous neurological conditions and alleviate ageing-related …

Introduction The 18-kDa translocator protein (TSPO) is increasingly recognized as a
molecular target for PET imaging of inflammatory responses in various central nervous …

Background Regulating the microglial phenotype is an attractive strategy for treating
diseases of the central nervous system such as depression and anxiety. Gastrodin can …

Increasing evidence supports the notion that neuroinflammation plays a critical role in the
etiology of major depressive disorder (MDD), at least in a subset of patients. By virtue of their …

Microglia, the resident immune cells of the central nervous system (CNS), are primarily
derived from the embryonic yolk sac and make their way to the CNS during early …