Insulin-like growth factors (IGFs) are key growth-promoting peptides that act as both
endocrine hormones and autocrine/paracrine growth factors. In the bloodstream and in local …

The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs)
were originally characterized as passive reservoirs of circulating IGFs, but they are now …

In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell
activity in various ways. By sequestering IGFs away from the type I IGF receptor, they may …

INSULIN-LIKE growth factor-I (IGF-I) and IGF-II growth factors that are structurally related to
insulin (Table 1). The human IGFs (refered to generically as somatomedins) are single chain …

Insulin-Like Growth Factor-Binding Proteins in Serum and Other Biological Fluids: Regulation
and Functions* | Endocrine Reviews | Oxford Academic Skip to Main Content Advertisement …

The environment in which the fetus develops is critical for its survival and long-term health.
The regulation of normal human fetal growth involves many multidirectional interactions …

The insulin-like growth factor (IGF) system plays a central role in the neuroendocrine
regulation of growth in all vertebrates. Evidence from studies in a variety of vertebrate …

The insulin-like growth factors (IGFs), IGF-I and IGF-II, comprise a conserved pair of secreted
proteins with diverse effects on growth, development, and metabolism. Insulin-like growth …

Publisher Summary Phage display, as it is practiced today for the selection of naive peptide
binders, mirrors the natural immune system. A large and diverse set of peptides can be …

Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated
protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are …