Amyloid precursor protein (APP) gives rise to the amyloid-β peptide and thus has a key role
in the pathogenesis of Alzheimer disease. By contrast, the physiological functions of APP …

In Alzheimer's disease (AD), early synaptic dysfunction is associated with the increased
oligomeric amyloid-beta peptide, which causes NMDAR-dependent synaptic depression …

Lysosome dysfunction arises early and propels Alzheimer's disease (AD). Herein, we show
that amyloid precursor protein (APP), linked to early-onset AD in Down syndrome (DS), acts …

Stroke and late-onset Alzheimer's disease (AD) are risk factors for each other; the
comorbidity of these brain disorders in aging individuals represents a significant challenge …

Most neurodegenerative diseases are proteinopathies, which are characterized by the
aggregation of misfolded proteins. Although many proteins have an intrinsic propensity to …

The generation of amyloid β-peptide (Aβ) by enzymatic cleavages of the β-amyloid
precursor protein (APP) has been at the center of Alzheimer's disease (AD) research. While …

NMDA receptor (NMDAR)-induced excitotoxicity is thought to contribute to the cell death
associated with certain neurodegenerative diseases, stroke, epilepsy, and traumatic brain …

β‐amyloid (Aβ) is widely accepted to be one of the major pathomechanisms underlying
Alzheimer's disease (AD), although there is presently lively debate regarding the relative …

N-methyl-d-aspartate receptors (NMDARs) play a pivotal role in the synaptic transmission
and synaptic plasticity thought to underlie learning and memory. NMDARs activation has …

Alzheimer disease is the most prevalent form of dementia globally and is characterized
premortem by a gradual memory loss and deterioration of higher cognitive functions and …