S100A8 and S100A9 in Cancer

Y Chen, Y Ouyang, Z Li, X Wang, J Ma - Biochimica et Biophysica Acta …, 2023 - Elsevier
Abstract S100A8 and S100A9 are Ca 2+ binding proteins that belong to the S100 family.
Primarily expressed in neutrophils and monocytes, S100A8 and S100A9 play critical roles in …

Pathogenic roles of S100A8 and S100A9 proteins in acute myeloid and lymphoid leukemia: clinical and therapeutic impacts

J Mondet, S Chevalier, P Mossuz - Molecules, 2021 - mdpi.com
Deregulations of the expression of the S100A8 and S100A9 genes and/or proteins, as well
as changes in their plasma levels or their levels of secretion in the bone marrow …

[HTML][HTML] Intratumoral combination therapy with poly (I: C) and resiquimod synergistically triggers tumor-associated macrophages for effective systemic antitumoral …

C Anfray, F Mainini, E Digifico, A Maeda… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Tumor-associated macrophages (TAMs) play a key immunosuppressive role
that limits the ability of the immune system to fight cancer and hinder the antitumoral efficacy …

The functions and regulatory pathways of S100A8/A9 and its receptors in cancers

H Zhou, C Zhao, R Shao, Y Xu, W Zhao - Frontiers in Pharmacology, 2023 - frontiersin.org
Inflammation primarily influences the initiation, progression, and deterioration of many
human diseases, and immune cells are the principal forces that modulate the balance of …

S100A8 and S100A9 in hematologic Malignancies: from development to therapy

F Razmkhah, S Kim, S Lim, AJ Dania… - International journal of …, 2023 - mdpi.com
S100A8 and S100A9 are multifunctional proteins that can initiate various signaling
pathways and modulate cell function both inside and outside immune cells, depending on …

Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastoma

B Du, F Zhang, Q Zhou, W Cheng, Z Yu, L Li, J Yang… - Scientific Reports, 2023 - nature.com
High-risk neuroblastoma (HR-NB) has a significantly lower survival rate compared to low-
and intermediate-risk NB (LIR-NB) due to the lack of risk classification diagnostic models …

Der f 38 Is a Novel TLR4-Binding Allergen Related to Allergy Pathogenesis from Dermatophagoides farinae

G Kim, M Hong, A Kashif, Y Hong, BS Park… - International Journal of …, 2021 - mdpi.com
It is difficult to treat allergic diseases including asthma completely because its pathogenesis
remains unclear. House dust mite (HDM) is a critical allergen and Toll-like receptor (TLR) 4 …

Pathogenic mechanism of Der p 38 as a novel allergen homologous to RipA and RipB proteins in atopic dermatitis

H Jeon, G Kim, A Kashif, MH Hong, JS Lee… - Frontiers in …, 2021 - frontiersin.org
Atopic dermatitis (AD) is a chronic relapsing pruritic disease encompassing skin
inflammation and barrier dysfunction. House dust mites are key allergens that augment the …

Toll-like receptor 4 as a favorable prognostic marker in bladder cancer: A multi-omics analysis

JL Lu, QD **a, Y Sun, Y Xun, HL Hu, CQ Liu… - Frontiers in cell and …, 2021 - frontiersin.org
Background The toll-like receptor 4 (TLR4) agonist, Bacille Calmette-Guérin, has exhibited
gratifying effects in treating bladder cancer. The study aims to explore the expression …

Fra‐1 induces apoptosis and neuroinflammation by targeting S100A8 to modulate TLR4 pathways in spinal cord ischemia/reperfusion injury

Y Chen, Y Dong, ZL Zhang, J Han, FS Chen… - Brain …, 2023 - Wiley Online Library
Spinal cord ischemia/reperfusion injury (SCII) is a severe complication driven by apoptosis
and neuroinflammation. An increase in the expression of c‐Fos, a member of the AP‐1 …