Pain is an unpleasant sensory and emotional experience associated with actual or potential
tissue damage. Chronic pain, with a prevalence of 20–30% is the major cause of human …

Pain is a multidimensional experience with sensory-discriminative, affective-motivational,
and cognitive-evaluative components. Pain aversiveness is one principal cause of suffering …

The central mechanisms underlying pain chronicity remain elusive. Here, we identify a
reciprocal neuronal circuit in mice between the anterior cingulate cortex (ACC) and the …

Co-occurrence of chronic pain and clinically significant symptoms of anxiety and/or
depression is regularly noted in the literature. Yet, little is known empirically about …

Importance Chronic back pain (CBP) is a leading cause of disability, and treatment is often
ineffective. Approximately 85% of cases are primary CBP, for which peripheral etiology …

Introduction Worldwide, more than 20 million patients undergo groin hernia repair annually.
The many different approaches, treatment indications and a significant array of techniques …

Chronic pain affects a large part of the population causing functional disability, being often
associated with coexisting psychological disorders, such as depression and anxiety …

The prefrontal cortex (PFC) is a complex brain region that regulates diverse functions
ranging from cognition, emotion and executive action to even pain processing. To decode …

Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …

Chronic pain is a condition in which pain progresses from an acute to chronic state and
persists beyond the healing process. Chronic pain impairs function and decreases patients' …