Alzheimer's disease: How metal ions define β-amyloid function

KP Kepp - Coordination Chemistry Reviews, 2017 - Elsevier
Alzheimer's disease is increasingly recognized to be linked to the function and status of
metal ions, and recently, the amyloid hypothesis has been strongly intertwined with the …

Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level

E Atrián-Blasco, A Conte-Daban, C Hureau - Dalton transactions, 2017 - pubs.rsc.org
While metal ions such as copper and zinc are essential in biology, they are also linked to
several amyloid-related diseases, including Alzheimer's disease (AD). Zinc and copper can …

A new fluorene derived Schiff-base as a dual selective fluorescent probe for Cu2+ and CN−

FN Moghadam, M Amirnasr, S Meghdadi… - … Acta Part A: Molecular …, 2019 - Elsevier
A new fluorene based fluorogenic chemosensor, 2-[(9H-Fluoren-2-ylmethylene)-amino]-
phenol (L), has been designed, synthesized, and characterized by CHN analyses and …

[HTML][HTML] Novel Fluorescence Probe toward Cu2+ Based on Fluorescein Derivatives and Its Bioimaging in Cells

X Leng, D Wang, Z Mi, Y Zhang, B Yang, F Chen - Biosensors, 2022 - mdpi.com
Copper is an important trace element that plays a crucial role in various physiological and
biochemical processes in the body. The level of copper content is significantly related to …

Insight into triphenylamine and coumarin serving as copper (II) sensors with “OFF” strategy and for bio-imaging in living cells

H Chen, P Yang, Y Li, L Zhang, F Ding, X He… - Spectrochimica Acta Part …, 2020 - Elsevier
Chemosensing is one of the widest and powerful techniques for response to anions and
cations in living systems serving as bio-probes. Meanwhile, copper (II)(Cu (II)) widely exists …

Novel alkyl-substituted 4-methoxy benzaldehyde thiosemicarbazones: Multi-target directed ligands for the treatment of Alzheimer's disease

M Varma, V Ugale, J Shaukat, M Hollmann… - European Journal of …, 2023 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative disorder affecting mental
ability and interrupts neurocognitive functions. Treating multifactorial conditions of AD with a …

A Highly Sensitive and Selective Fluorescein-Based Cu2+ Probe and Its Bioimaging in Cell

X Leng, M She, X **, J Chen, X Ma, F Chen, J Li… - Frontiers in …, 2022 - frontiersin.org
Copper is a vital trace metal in human body, which plays the significant roles in amounts of
physiological and pathological processes. The application of copper-selective probe has …

Tracking mitochondrial Cu (I) fluctuations through a ratiometric fluorescent probe in AD model cells: Towards understanding how AβOs induce mitochondrial Cu (I) …

Q Zhao, L Ma, S Chen, L Huang, G She, Y Sun, W Shi… - Talanta, 2024 - Elsevier
Mitochondrial copper signaling pathway plays a role in Alzheimer's disease (AD), especially
in relevant Amyloid-β oligomers (AβOs) neurotoxicity and mitochondrial dysfunction …

A Trishistidine Pseudopeptide with Ability to Remove Both CuΙ and CuΙΙ from the Amyloid‐β Peptide and to Stop the Associated ROS Formation

A Conte‐Daban, B Boff… - … A European Journal, 2017 - Wiley Online Library
The pseudopeptide L, derived from a nitrilotriacetic acid scaffold and functionalized with
three histidine moieties, is reminiscent of the amino acid side chains encountered in the …

Meso pyridinium BODIPY-based long wavelength infrared mitochondria-targeting fluorescent probe with high photostability

S Jiao, X Dong, W Zhao - Analytical Methods, 2023 - pubs.rsc.org
Mito-tracker deep red (MTDR) as a commercially available mitochondria-targeting probe
was easily bleached upon imaging. We designed and synthesized a family of meso …