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Ocular indicators of Alzheimer's: exploring disease in the retina
Although historically perceived as a disorder confined to the brain, our understanding of
Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with …
Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with …
Dementia in Latin America: assessing the present and envisioning the future
The demographic structure of Latin American countries (LAC) is fast approaching that of
develo** countries, and the predicted prevalence of dementia in the former already …
develo** countries, and the predicted prevalence of dementia in the former already …
Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging
Aging is a major risk factor to develop neurodegenerative diseases and is associated with
decreased buffering capacity of the proteostasis network. We investigated the significance of …
decreased buffering capacity of the proteostasis network. We investigated the significance of …
Amyloid β-protein oligomers and Alzheimer's disease
The oligomer cascade hypothesis, which states that oligomers are the initiating pathologic
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
agents in Alzheimer's disease, has all but supplanted the amyloid cascade hypothesis …
Alzheimer's retinopathy: seeing disease in the eyes
The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …
Deregulation of mitochondrial F1FO-ATP synthase via OSCP in Alzheimer's disease
Abstract F1FO-ATP synthase is critical for mitochondrial functions. The deregulation of this
enzyme results in dampened mitochondrial oxidative phosphorylation (OXPHOS) and …
enzyme results in dampened mitochondrial oxidative phosphorylation (OXPHOS) and …
Retinal vasculopathy in Alzheimer's disease
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …
Pathology of the aging brain in domestic and laboratory animals, and animal models of human neurodegenerative diseases
SA Youssef, MT Capucchio, JE Rofina… - Veterinary …, 2016 - journals.sagepub.com
According to the WHO, the proportion of people over 60 years is increasing and expected to
reach 22% of total world's population in 2050. In parallel, recent animal demographic …
reach 22% of total world's population in 2050. In parallel, recent animal demographic …
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents
We have synthesized a family of rhein–huprine hybrids to hit several key targets for
Alzheimer's disease. Biological screening performed in vitro and in Escherichia coli cells …
Alzheimer's disease. Biological screening performed in vitro and in Escherichia coli cells …
Alzheimer's disease mechanisms and emerging roads to novel therapeutics
Ten years of remarkable progress in understanding the fundamental biochemistry of
Alzheimer's disease have been followed by ten years of remarkable and increasing clinical …
Alzheimer's disease have been followed by ten years of remarkable and increasing clinical …