Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease
MA Felmlee, RS Jones, V Rodriguez-Cruz… - Pharmacological …, 2020 - Elsevier
The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate
transporter (MCT) family that play an essential role in the transport of important cell nutrients …
transporter (MCT) family that play an essential role in the transport of important cell nutrients …
[HTML][HTML] Thyroid hormone regulation of metabolism
R Mullur, YY Liu, GA Brent - Physiological reviews, 2014 - journals.physiology.org
Thyroid hormone (TH) is required for normal development as well as regulating metabolism
in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially …
in the adult. The thyroid hormone receptor (TR) isoforms, α and β, are differentially …
Role of thyroid hormones in skeletal development and bone maintenance
JHD Bassett, GR Williams - Endocrine reviews, 2016 - academic.oup.com
The skeleton is an exquisitely sensitive and archetypal T3-target tissue that demonstrates
the critical role for thyroid hormones during development, linear growth, and adult bone …
the critical role for thyroid hormones during development, linear growth, and adult bone …
Paradigms of dynamic control of thyroid hormone signaling
Thyroid hormone (TH) molecules enter cells via membrane transporters and, depending on
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …
the cell type, can be activated (ie, T4 to T3 conversion) or inactivated (ie, T3 to 3, 3′-diiodo-l …
Thyroid hormone transporters
S Groeneweg, FS van Geest, RP Peeters… - Endocrine …, 2020 - academic.oup.com
Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …
thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion …
Thyroid hormone transporters—functions and clinical implications
J Bernal, A Guadaño-Ferraz, B Morte - Nature Reviews Endocrinology, 2015 - nature.com
The cellular influx and efflux of thyroid hormones are facilitated by transmembrane protein
transporters. Of these transporters, monocarboxylate transporter 8 (MCT8) is the only one …
transporters. Of these transporters, monocarboxylate transporter 8 (MCT8) is the only one …
Thyroid hormone receptors in brain development and function
J Bernal - Nature clinical practice Endocrinology & metabolism, 2007 - nature.com
Thyroid hormones are important during development of the mammalian brain, acting on
migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of …
migration and differentiation of neural cells, synaptogenesis, and myelination. The actions of …
Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling
B Gereben, AM Zavacki, S Ribich, BW Kim… - Endocrine …, 2008 - academic.oup.com
The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore
are critical for the biological effects mediated by thyroid hormone. Over the years, research …
are critical for the biological effects mediated by thyroid hormone. Over the years, research …
Hypothalamus‐pituitary‐thyroid axis
The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …
Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier
Inactivating mutations in the thyroid hormone (TH) transporter Monocarboxylate transporter
8 (MCT8) cause severe psychomotor retardation in children. Animal models do not reflect …
8 (MCT8) cause severe psychomotor retardation in children. Animal models do not reflect …