Role of metal cations of copper, iron, and aluminum and multifunctional ligands in Alzheimer's disease: Experimental and computational insights

N Puentes-Díaz, D Chaparro, D Morales-Morales… - ACS …, 2023 - ACS Publications
Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people
around the world. Even though the causes of AD are not completely understood due to its …

Specific Binding of Alzheimer's Aβ Peptides to Extracellular Vesicles

C Coughlan, J Lindenberger, JG Jacot… - International Journal of …, 2024 - mdpi.com
Alzheimer's disease (AD) is the fifth leading cause of death among adults aged 65 and
older, yet the onset and progression of the disease is poorly understood. What is known is …

Polyphenols with anti-inflammatory properties: synthesis and biological activity of novel curcumin derivatives

Y González, R Mojica-Flores… - International Journal of …, 2023 - mdpi.com
Herein, we describe the synthesis and evaluation of anti-inflammatory activities of new
curcumin derivatives. The thirteen curcumin derivatives were synthesized by Steglich …

Effect of caffeine on the aggregation of amyloid-β–A 3D RISM study

P Dey, P Biswas - The Journal of Chemical Physics, 2024 - pubs.aip.org
Alzheimer's disease is a detrimental neurological disorder caused by the formation of
amyloid fibrils due to the aggregation of amyloid-β peptide. The primary therapeutic …

The role of carotenoids from red mamey fruit (Pouteria sapota) against amyloid-β monomers in Alzheimer's disease: Computational analysis and ADMET prediction

AL Orjuela, M Pecchio, J Cruz-Mora… - Journal of …, 2024 - journals.sagepub.com
Background Carotenoids, potent antioxidants in fruits and vegetables, have recently
garnered attention for their potential therapeutic effects against neurodegenerative …

In Silico Analysis of Curcumin's Targeted Cancer Therapy: Folate Receptor Pathways and Molecular Interaction Insights

KJ Rajimon, R Almeer, P Thangaiyan… - Chemistry & …, 2024 - Wiley Online Library
This study explores the therapeutic potential of curcumin (CUR) in cancer therapy,
specifically examining its targeted transport through folate receptors and its interaction with …

π-stacking interactions between curcumin and aromatic ring of amino acids in amyloid fibrils: A theoretical study

ZR Sarvestani, M Hashemi, Z Solati - Computational and Theoretical …, 2023 - Elsevier
The aggregation of amyloid-β peptides into amyloid fibrils is considered as one of the
possible causes of Alzheimer's disease. Curcumin is a well-known inhibitor for aggregation …

Identification of Novel Peptides as Potential Modulators of Aβ42 Amyloidogenesis: An in silico Approach

K Kundal, S Paramasivam, A Mitra… - … Computer-Aided Drug …, 2023 - benthamdirect.com
Aims: Alzheimer's disease is a neurodegenerative disease for which no cure is available.
The presence of amyloid plaques in the extracellular space of neural cells is the key feature …

Investigação do papel dos astrócitos nas fases iniciais da doença de Alzheimer: curcumina como estratégia protetora e avaliação dos seus mecanismos moleculares

JH Taday - 2024 - lume.ufrgs.br
As doenças neurodegenerativas são condições complexas e multifatoriais, frequentemente
diagnosticadas em estágios avançados, quando os sintomas já são graves. Entretanto …

[PDF][PDF] Identification of the microsatellite stability status and inhibitor of NF-kappa-B expression levels as biomarkers to predict sensitivity to pharmaceutical curcumin in …

L Lu - 2021 - rosdok.uni-rostock.de
Identification of the microsatellite stability status and inhibitor of NF-kappa-B expression levels as
biomarkers to predict sen Page 1 Universitätsmedizin Rostock Abteilung für Allgemein-, Viszeral …