Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Fibroblast growth factor 21 (FGF21) is a hormone that is involved in the regulation of lipid,
glucose, and energy metabolism. Pharmacological FGF21 administration promotes weight …

The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for
obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate …

It is widely acknowledged that the ketogenic diet (KD) has positive physiological effects as
well as therapeutic benefits, particularly in the treatment of chronic diseases. Maintaining …

Background The hypothalamic–pituitary–adrenal (HPA) axis is a neuroendocrine system
involved in controlling stress responses in humans under physiological and pathological …

Whereas carbohydrates and lipids are stored as glycogen and fat, there is no analogous
inert storage form of protein. Therefore, continuous adjustments in feeding behavior are …

The mitochondrial pyruvate carrier (MPC) is the entry point for the glycolytic end-product
pyruvate to the mitochondria. MPC activity, which is controlled by its abundance and post …

Background: The ketogenic diet (KD) has been highly developed in the past for the
treatment of epileptic pathological states in children and adults. Recently, the current re …

Alcohol use disorder (AUD) is a chronic, relapsing brain disorder, characterized by
compulsive alcohol seeking and disrupted brain function. In individuals with AUD …

Decreases in energy metabolism following traumatic brain injury (TBI) are attributed to
impairment of glycolytic flux and oxidative phosphorylation. Glucose utilization post-TBI is …